Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2015, Vol 5, Issue 4
Abstract
Background: Ganoderma lucidum, commonly referred to as Lingzhi in China, is a fungus that has been widely used through the centuries for the general promotion of health and longevity in Asian countries. Aims and Objective: To determine the effects of subchronic exposure of PSP G. lucidum on renal function and renal histopathology feature in Rattus novergicus Wistar strain. Materials and Methods: A total of 80 male and female Wistar rats, aged 2–3 months with a body weight of 200–300 g, were divided into four treatment groups: dose group 0 (control group), group PSP G. lucidum dose of 300, 600, and 1200 mg/kg for 90 days. Parameters measured were urea and creatinine levels and renal histopathology feature. Result: From the research, the highest urea levels were found in the group in which female Wistar rats were treated with PSP dose of 300 mg/kg/day with an average concentration of urea of 33.2 mg/dL, whereas creatinine levels were found to be equally high on treatment with PSP dose of 1200, 600, and 300 mg/kg/day with an average concentration of urea of 0.3 mg/dL. On histopathological examination, no morphological abnormalities were found. The results of one-way analysis of variance test showed no significant difference at all PSP G. lucidum doses. Conclusion: It is concluded that giving PSP G. lucidum in three variant doses does not cause dysfunction and histological damage to the renal function.
Authors and Affiliations
Titin Andri Wihastuti, Djanggan Sargowo, Mohammad Aris Widodo, Teuku Heriansyah, Setyowati Soeharto, Kenti Wantri Anita, Novita Qurrota A’ini
Keywords
Related Articles
- EP ID EP112466
- DOI 10.5455/njppp.2015.5.0603201539
- Views 67
- Downloads 0
Insulin resistance and blood lipid levels during fasting
Background: Fasting is observed by Muslims during Ramzan. Here, they do not consume food and drinks. It is observed for 29–30 days. The fast begins early in the morning and lasts until evening. Aims and Objectives: This...
Impact of stroke on quality of life and functional independence
Background: Cerebrovascular accident is the prime cause for the functional disability and deteriorated quality of life (QOL) which affects person’s social and physical capabilities. Present stroke outcomes are restricted...
Antifungal properties of soleshine - An in vitro study
Background: Soleshine is a polyherbal formulation meant to be used to heal cracks on heels, protecting sole from chaffs, marketed by Rumi Herbal Pvt Ltd., Chennai. The active ingriedients are Azadirachta indica, Lawsonia...
A prospective study of the pattern of antimicrobial use in neonatal intensive care unit of a tertiary care hospital
Background: Neonatal intensive care management (NICM) involves the use of a multiplicity of medications of different categories. Antimicrobial agents (AMAs) are the most frequently prescribed during NICM, either for prop...
The effect of cognitive behavioral consultation on marital quality among women
Background: Marital quality reflects the individual’s total evaluation of marital relationship. The present study was carried out to examine the effect of cognitive behavioral consultation on marital quality among women....