Formulation and Evaluation of Aluminum Adjuvanted Combination Vaccine with Reduced Freeze Sensitivity
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 5
Abstract
Objective of present study is to formulate and evaluate freeze thaw resistant combination vaccine comprises of Diphtheria, tetanus, whole cell pertussis, hepatitis B and haemophilus type b conjugate vaccines. Use of surfactants, sugars, polyols and their combinations to protect vaccines from freezing effects was proved. Freeze thaw resistant combination vaccine prepared by adding novel non ionic block copolymer polaxamer. Presence of polaxamer block copolymer exerts resistance from damage caused by freezing and thawing to aluminum adjuvanted vaccine. Polaxamer 407 itself in high concentrations found suitable to reduce freeze sensitivity. Use of high concentrations of polaxamer block copolymer with concentrated formulation helps in making vaccine freeze thaw resistant up to three freeze thaw cycles. Use of high concentration of polaxamer, thermo reversible nature of polaxamer block copolymer and viscosity modification helps in heat stability improvement as well. Concentratedn formulation developed can be easily diluted or re-suspended with suitable diluent to make final vaccine with required concentration for immunization and also reduces polaxamer concentration to suitable level for human parenteral use. Polaxamer block copolymer gives advantage for easy dispersion of vaccine and making uniform suspension post re-suspension.
Authors and Affiliations
Sujana Prasad Chittineni1 *, Satish Chandra Maheshwari2 , Lakshmi Narasu mangamoori3
Keywords
Related Articles
- EP ID EP126475
- DOI -
- Views 100
- Downloads 0
Host Modulation- Promising Direction In Periodontal Therapy
: The primary etiology of the periodontal disease is chronic inflammation due to bacterial infection. It is the host’s reaction to the presence of bacteria that mediates tissue destruction .Since the destruction...
Determining the Phytochemical Constituents and the Antimicrobial Activity of Ethanolic Extract of Acassia Leaf (Senna Siamea) On Some Enterobacteriaceae
ABSTRACT: Microorganisms are known to cause different types of infection in both humans and animals. The use of medicinal plants to prevent and treat such infections is increasing. This study was aimed at ...
Nutrient And Anti-Nutrient Compositions Of Brassica Oleracae Var. Capitata L.
ABSTRACT: The proximate, mineral, vitamin and anti-nutrient compositions of Brassica oleracae var. capitata L. were evaluated using standard procedures. The result for the proximate composition showed the con...
Cancer preventive Effect of Morinda citrifolia (Noni) fruit juice against the AflatoxinB1-induced genotoxicity in human peripheral lymphocytes in vitro.
Outcome of pregnancy among Pre-existing Type-2 Diabetic Women
Background: Diabetes mellitus is now one of the most common non-communicable diseases globally. As diabetes is a chronic and debilitating disease, it may have adverse effect on pregnancy and pregnancy outcomes. Aim...