FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET BY INCLUSION COMPLEXATION
Journal Title: Asian J of Pharm Sci & Tech - Year 2014, Vol 4, Issue 1
Abstract
ABSTRACT Glimepiride (GMP) is third Generation sulphonyl ureas used for treatment of type 2 diabetes. Poor water solubility is the main constant for its oral bioavailability. The rationale of this study to enhance solubility and dissolution of the drug by preparing its complex with β cyclodextrin. In the present study attempt has been made to prepare, formulate and characterize inclusion complex of glimepiride with β cyclodextrin. The inclusion complex prepared by kneading method. The inclusion complex containing Glimepiride:β cyclodextrin (1:5) was further formulated into fast dissolving tablet by direct compression technique using superdisintegrant like sodium starch glycolate. The prepared complex were characterize using FT-IR, DSC and finally fast dissolving tablet were evaluated for various pharmaceutical characteristics viz. Hardness, % Friability, Weight variation, Wetting time, Drug content and in-vitro dissolution profiles. Key words: Fast dissolving tablet, Glimepiride, Kneading method, β cyclodextrin superdisintegrants.
Authors and Affiliations
Narendra Rajput, VM Thakare*, BW Tekade, KP Chaudhari, UT Jadhao
Keywords
Related Articles
- EP ID EP149308
- DOI -
- Views 148
- Downloads 0
EFFECT OF ETHANOLIC EXTRACT OF FLOWERS OF TECOMA STANS ON ACETIC ACID INDUCED COLITIS IN ALBINO RATS
ABSTRACT Aim to evaluate the effect of ethanolic extract of flowers of Tecoma stans on acetic acid induced colitis in albino rats. Ethanolic extract of Tecoma stans (EETS) was prepared by percolation method. Acut...
ANTOBODY RESPONSE OF ACHYRANTHES ASPERA LINN. TO AEROMONAS HYDROPHILA IN OREOCHROMIS MOSSAMBICUS
ABSTRACT Fish is the cheapest and most easily digestible animal protein and was obtained from natural sources from time immemorial for consumption by human beings. Fish culture can be taken as a major economic ac...
ANTICANCER EFFECT OF THE MARINE MICRO ALGA, SKELETONEMA COSTATUM (GREVILLE) CLEVE ON HUMAN CERVICAL CANCER CELL LINE
ABSTRACT Marine organisms are rich sources of new, biologically active compounds. Phytoplanktons have traditionally been used as foods. Recently, much attention has been paid to the anticancer activity of Phytopl...
CURRENT REGULATIONS FOR MARKETING AUTHORIZATION OF HUMAN GENERIC PRODUCTS GLOBALLY AS PER WHO
ABSTRACT Generic medicines are those where patent protection has expired, and which may be produced by manufacturers other than the innovator company. Use of generic medicines has been increasing in recent years,...
PHYTOCHEMICAL SCREENING, ANTIBACTERIAL EVALUATION AND IN VITRO SPASMODIC EFFECT OF THE AQUEOUS AND ETHANOL LEAF AND BARK EXTRACTS OF ANOGEISSUS LEIOCARPUS (DC.) GUILL. & PERR.
ABSTRACT Anogeissus leiocarpus is a graceful tree of Africa, commonly known as “Axle wood tree or African birch” belonging to the family Combrateceae. It is a tall evergreen tree native to savannah of tropical Af...