FORMULATION AND EVALUATION OF MIGLITOL SUSTAINED RELEASE TABLETS

Journal Title: Asian J of Pharm Sci & Tech - Year 2013, Vol 3, Issue 2

Abstract

 ABSTRACT The purpose of the present study was to develop sustained release tablets of Miglitol, an anti-diabetic drug which are designed for better management of diabetes mellitus to minimize side effects, to improve patient compliance and preventing the fluctuation of therapeutic concentration of the drug in the body. The Miglitol sustained release tablets (F1 – F7) were prepared by wet granulation method using HPMC K15M and Hydroxy methyl cellulose E5 polymers in different ratios of (1:1, 1:2 and 1:3). Granules were performed by Preformulation studies. The Miglitol sustained release tablets were evaluated for hardness, friability, weight variation, drug content and In-vitro dissolution study. The Miglitol sustained release tablets showed drug release from 28.68 to 97.43% of drug at the end of 24thhr byin-vitrodissolution study. The formulation F7 was selected as an optimized formulation because it gives the best result in terms of drug release in sustained release manner. The kinetic release treatment showed that the release of drug follows zero order kinetic (R2 value as 0.985), korsemeyer equation gave value of (R2 = 0.950) which was close to one indicating that the drug was released by zero order kinetic and Short term stability studies indicated that there is no appreciable changes in the drug content and in vitro drug release rates of optimized formulation F7. Key words: Miglitol, HPMC K15M, HMC E5, Wet Granulation Method, Sustained Release.

Authors and Affiliations

*Rangasamy Manivannan, Kotha Aravind Kumar, Bandaru Lakshmi Narayana Rao and Palnati Venkata Krishna Reddy

Keywords

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  • EP ID EP112559
  • DOI -
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How To Cite

*Rangasamy Manivannan, Kotha Aravind Kumar, Bandaru Lakshmi Narayana Rao and Palnati Venkata Krishna Reddy (2013).  FORMULATION AND EVALUATION OF MIGLITOL SUSTAINED RELEASE TABLETS. Asian J of Pharm Sci & Tech, 3(2), 62-66. https://europub.co.uk./articles/-A-112559