FORMULATION AND EVALUATION OF SUSTAINED RELEASE FLOATING TABLETS OF CIPROFLOXACIN WITH HEPATO-PROTECTANT
Journal Title: International Journal of Pharmaceutical Applications - Year 2012, Vol 3, Issue 1
Abstract
The study was taken up with a view to increase the elimination half-life of the antibiotics which would provide consistent and prolonged plasma drug concentrations in the body. In the present research work formulation and evaluation of sustained release floating matrix tablets of Ciprofloxacin has been done. Sodium bicarbonate is used in the formulations as a source of Carbondioxide. Ciprofloxacin has been selected as the drug of choice owing to the fact that it is having a bioavailability of only 60%. It is stable at the gastric pH (acidic 1.2) and is having an elimination half-life of 7 hours. It is soluble in acidic medium and thus a floating tablet of the drug would increase the extent of Absorption. The matrix type of system is prepared with the help of swell-able polymer hydroxypropylmethylcellulose k15M. It is formulated in such a way that when in contact with the acidic gastric contents, CO2 is liberated and gets entrapped in swollen hydrocolloid, which provides buoyancy to the dosage forms. More over DL-methionine has been added as a hepato- protective agent that makes the formulation a unique one. The resulting formulation has been evaluated for all the necessary parameters like Weight variation , Thickness, Hardness, Friability, Drug content uniformity, Floating lag time, Floating duration time. Besides the above tests other parameters, dissolution studies and in-vitro drug release also has been conducted successfully. Thus the above formulation has been proven to be much more superior to the existing tablet forms.
Authors and Affiliations
E Sathish Reddy , Mohammed Majid Iqbal , Syed Mohammed Kazim , Syed Asad B , Mohammed Ibrahim
Keywords
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