Abstract

 ABSTRACT The present study was aim to formulate and evaluate the sustained release oral matrix tablet by using rifampicin as a model drug and see the effects of different polymers to prolong the release of drug for extended period of time in order to formulate the sustained release dosage form of rifampicin, improve patient compliance, ease of administration, reduce dosing frequency, increase bioavailability of drug. Based on preformulation studies different batches of rifampicin were prepared using selected excipients. Granules were evaluated for tests Bulk density, tapped density, compressibility index, Hausner ratio before being punched as tablets. Various formulations of sustained release tablets of rifampicin were developed using various polymers viz, Guar gum, Tragacanth Gum, PEG-6000 and Carbopol in different proportions and combinations by direct compression technique. The tablets were evaluated for physical characterization, in vitro swelling behavior, in vitro release study and stability studies. Results of in vitro release profile indicated that formulation (F2) was the most promising formulation as the extent of drug release from this formulation was high as compared to other formulations. Results of in vitro swelling study indicate that the formulation F2 was having considerable swelling index. It is concluded that formulation of sustained release tablet of Rifampicin containing Guar gum (1.5%), batch F2 can be taken as an ideal or optimized formulation of sustained release tablets for 12 hour release as it fulfills all the requirements for sustained release tablet. Key words: Rifampicin, Preformulation studies, in vitro release study, antitubercular agent.

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