Formulation Properties of Acetylsalicylic Acid Tablet Using Novel Starch from Cola nitida
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 6
Abstract
ABSTRACT: The nut of Cola nitida Vent was extracted and examined for its starch constituent and physicochemical properties. The starch was isolated using 1%w/v sodium metabisulphite solution. The starch obtained had a fine texture, white, tasteless and odourless with a pH of 5.5 and moisture content of 9.67%. 75 mg acetylsalicylic acid tablet was formulated with novel starch using direct compression method. The formulated tablets conform to the pharmacopoeia standard for weight uniformity, disintegration time, friabilityand hardness. The values obtained from the test sample tablet were compared with the values obtained from 3 other brands of 75 mg acetylsalicylic acid tablet bought from the market. ANOVA with Duncan Hoc test was performed on graphpad instat software to determine the statistical comparison among the samples at p < 0.05. Values were represented as mean ± standard deviation. There was no significant (P>0.05) difference in the disintegration and hardness profiles of the test sample and most of the commercial brands of acetylsalicylic acid tablets.
Authors and Affiliations
¹Clement Jackson , ²Bernard Patani
Keywords
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