HEPATOPROTECTIVE ACTIVITY OF BOSWELLIA SERRATA EXTRACTS: IN VITRO AND IN VIVO STUDIES
Journal Title: International Journal of Pharmaceutical Applications - Year 2011, Vol 2, Issue 1
Abstract
AIM: To study the hepatoprotective activity of extracts of Boswellia Serrata in paracetamol treated male rats. METHODS: - The dried powder of Boswellia Serrata was extracted successively with different solvent systems and concentrated in vacuum. Primary rat hepatocyte monolayer cultures were used for in vitro studies. In vivo, the hepatoprotective capacity of the extracts of the Boswellia Serrata was analyzed in liver injured Paracetamol treated male rats. RESULTS: In vitro: primary hepatocytes monolayer cultures were treated with paracetamol and extracts of Boswellia Serrata. A protective activity could be demonstrated in the paracetamol damaged primary monolayer culture. In vivo: extracts of Boswellia Serrata were found to have protective properties in rats with paracetamol induced liver damage as compared from serum marker enzyme activities. CONCLUSION: The extracts of Boswellia Serrata do have a hepatoprotective activity both in vitro on primary hepatocytes cultures and in vivo in a rat model of paracetamol mediated liver injury.
Authors and Affiliations
Mohammed Ibrahim , Khaja Zeeya Uddin and Mangamoori Lakshmi Narasu
Keywords
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- EP ID EP86822
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