[i]FABRICATION AND CHARACTERISATION OF SUPRAMOLECULAR ASSEMBLY BETWEEN IBUPROFEN AND BETACYCLODEXTRINS[/i]
Journal Title: Asian J of Pharm Sci & Tech - Year 2013, Vol 3, Issue 1
Abstract
ABSTRACT Ibuprofen is a widely used non steroidal anti-inflammatory drug (NSAID), according to BCS classification it belongs to class – II having low solubility and high permeability. To enhance the solubility of poorly water soluble drugs various approaches are already in practices. Among those complexation process by supra molecular approach is the one of the solubility enhancement techniques. The aim of the study is to prepare and characterize the supra molecular assembly between Ibuprofen and Beta cyclodextrin. The main reason to move on with this aim is to enhance the solubility of the drug by complexation with Beta cyclodextrins the poor water soluble Ibuprofen is incorporated in the central hydrophobic core of Beta cyclodextrin and outer hydrophilic region of Beta cyclodextrin complex is exposed to aqueous environment thereby increasing the solubility and finally the bioavailability gets enhanced.The problem of poor solubility of Ibuprofen was resolved by preparing the Beta cyclodextrin complexes of Ibuprofen in different ratios by co grinding method. The poor aqueous solubility of Ibuprofen pose several difficulties in formulation process, so enhancement of aqueous solubility of Ibuprofen ultimately its bioavailability is the major goal. Prepared crystals are charecterised by FTIR, DSC and SEM studies, No interaction between ingredients was confirmed by FTIR, DSC. And also crystals are evaluated for solubility studies, drug content, and Invitro dissolution studies. Solubility studies evaluated for prepared complexes had higher solubility compared to pure drug. Highest percentage drug release was found to be 79.91% for formulation F3 prepared by co-grinding method and lowest percentage drug release was found to be 26.5% formulation F3 prepared by crystallization method. Key words: Ibuprofen, Beta-cd, Supra molecule, Inclusion complex, Crystillisation, In Vitro Release.
Authors and Affiliations
Niharika G*, Noor Ahmed VH, Sevukarajan M, Deepak P, Javeed khan, Shaaz Nazan, Shehnaz Begum
Keywords
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