MULTIVARIATE UV-VISIBLE SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF EMTRICITABINE IN BULK FORM
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2015, Vol 5, Issue 2
Abstract
ABSTRACT To develop a simple, precise and accurate UV-method with multivariate calibration technique for estimation of emtricitabine in bulk form. This technique is based on the use of the linear regression equations by using relationship between concentration and absorbance at five different wavelengths like 287, 289, 291, 293 and 295. The results were treated statistically and were found highly accurate, precise and reproducible. The emtricitabine shows absorption maxima at 291 nm and obeyed Beer’s law in the range of 1-10 µg/mL. The % recovery of capsules was found to be in the range of 99.16-100.41. The low % RSD values are indicates the accuracy and precise of the method. The proposed methods can be successfully applied for method development, validation and multivariate analysis of emtricitabine. Keywords: Emtricitabine, UV spectroscopy, Development, Validation and Multivariate technique.
Authors and Affiliations
K. Vijaya Sri,* M. Madhuri , G. Vinay jain
Keywords
Related Articles
- EP ID EP159432
- DOI -
- Views 107
- Downloads 0
PREPARATION AND EVALUATION OF GASTRORETENTIVE MUCOADHESIVE MICROSPHERES OF CAPTOPRIL
The aim of the present investigation was to evaluate the potential use of mucoadhesive microspheres for gastroretentive delivery of captopril. Chitosan was used as mucoadhesive polymers. The release of drug was p...
EFFECTIVE ANTIMICROBIAL THERAPY OF PERIODONTITIS - AN OVERVIEW OF DENTAL/PERIODONTAL CHIP
Periodontitis is an inflammatory response to bacteriological infections that destroys the attachment of teeth resulting inperiodontal pocket formation. Organisms responsible for periodontitis are aclinobacillus act...
PLANT AS A PLATFORM FOR PRODUCTION OF VACCINE
ABSTRACT Edible vaccines is a new concept for the formulation and development department in the pharmaceutical industry because it is easily available from plant, cost-effective, easy-to-administer, easy-to-store...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF RAMIPRIL HCL AND METOPROLAL TARTRATE IN PURE AND IN COMBINATIONS BY UV SPECTROPHOTOMETRY AND RP-HPLC
ABSTRACT Simple, rapid and accurate UV Spectroscopic (Simultaneous Equation method and First order derivative method) and an isocratic RP – HPLC methods showed excellent sensitivity, reproducibility, accuracy, an...
CONTRACT MANUFACTURING – A NEW ERA IN PHARMACEUTICAL MANUFACTURING
Contract manufacturing involves production of goods by firm, under the label or brand of another firm. Contract manufacturers provide such service to several firms based on their own or consumers’ designs, formul...