NANOPARTICLES AS SPECIFIED CARRIERS IN TARGETED BRAIN DRUG DELIVERY SYSTEM
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2013, Vol 3, Issue 1
Abstract
The blood brain barrier represents an insurmountable obstacle for a large number of drugs including antibiotics, anti neoplastics and a variety of CNS active drugs especially neuropeptides. One of the possibilities to overcome this barrier is a drug delivery to brain using nanoparticles. The use of nanoparticles to deliver drugs to the brain across the blood brain barrier may provide a significant advantage to current strategies. The primary advantage of nanoparticles carrier technology is that nanoparticles mask the blood brain barrier limiting the characteristics of the therapeutics, drug molecules and it also decreasing peripheral toxicity by causing slow drug release in the brain. The nanoparticles may be especially helpful for the treatment of the disseminated and very aggressive brain tumors. The mechanism of nanopraticles mediated transport of drugs is mostly endocytosis by endothelial cells lining the brain blood capillaries.
Authors and Affiliations
Shivaraju , GK Avinash , S Parthiban , SK Senthilkumar
Keywords
Related Articles
- EP ID EP105351
- DOI -
- Views 80
- Downloads 0
A RENEWABLE BIO-DIESEL FROM MICRO-ALGAE (A FUTURE’S NEED)
ABSTRACT Biodiesels (fatty acid methyl esters) derived from oleaginous microbes (microalgae, yeast, and bacteria) are being actively pursued as potential renewable substitutes for petroleum diesel. Continued use...
COMPARATIVE EVALUATION OF A COLORIMETRIC MICROTITRE PLATE ASSAY IN DETERMINING THE MINIMUM INHIBITION CONCENTRATION OF ANTIMICROBIALS AND PRESERVATIVES IN COSMETIC AND TOILETRY FORMULATIONS
ABSTRACT Preservatives and antimicrobials are commonly used in cosmetic and toiletry products in order to increase the shelf life of the products. Thus the effective concentration of these chemical agents is one...
A REVIEW ON NANOTECHNOLOGY IN SOLID LIPID NANOPARTICLES
This present review is progress in selected nanotechnology topics and some possible applications. This attempt mainly focused on solid lipid nanoparticles & different preparation methods of solid lipid nanopa...
ORAL MANIFESTATIONS OF DENGUE HAEMORRHAGIC FEVER: A REVIEW
ABSTRACT Dengue viral infection is a cause of considerable morbidity and mortality and may be associated with a variety of mucocutaneous manifestations that may provide important early clues to the diagnosis of t...
REGULATORY STRATEGIES FOR FILING OF NDA IN ICH COUNTRIES (US, EUROPE and JAPAN)
ABSTRACT Developing new drugs requires great amount of research work in Chemistry, Manufacturing, Controls, preclinical science and clinical trials. Drug reviewers in regulatory agencies around the world bear the...