NOVEL SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF SCHIFF BASE COMPLEXES OF 4-PYRIDINE CARBOXALDEHYDE
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2014, Vol 4, Issue 4
Abstract
ABSTRACT In the present study an intermolecular reductive Schiff base formation from 4-nitro pyridine and 4 pyridine carboxaldehyde carried out in the presence of iron powder and dilute acid. The Schiff base and metal complexes have been characterized by elemental analysis, molar conductance, molecular weight determination, IR, XRD and SEM. The biological activities have also been studied for the synthesized compounds. The Schiff base and its metal complexes show a good activity against the bacteria Staphylococcus aureus, E.coli, Klebsiella, Pneumonia and fungi like Candida albicans, Apergillus niger and Pencillium sp. The antimicrobial results also indicate that the metal complexes are better antimicrobial agents as compared to the Schiff base. Keywords: 4-Nitropyridine, 4-Pyridinecarboxaldehyde, Antimicrobial activity.
Authors and Affiliations
P. Venkateswara Rao1 , A. V. G. S. Prasad*1, P. S. S. Prasad2
Keywords
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