Protective Effect of Enzymatic Hydrolyzate of Chlorophytum Comosum (L.) Against Experimental Toxic Liver Injury In Wistar Rats At The Age Of 3 Months
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2013, Vol 3, Issue 8
Abstract
Researches of age-dependent changes of liver functions are an important issue of modern biomedicine. In this regard the researches of correction of these changes with use of various biologically active agents are also very actual. Investigation of the influence of the enzymatic hydrolyzate of Chlorophytum comosum (L.) on the liver of rats at the age of 3 months at its experimental toxic damage by CCl4 showed that the substrate has expressed hepatoprotective effect. At hydrolyzate application morphological changes in the rat liver with toxic damage are much less pronounced than in the controls. There are also less significant deviations from normal levels of Alanine transamilase (ALT), Alanine transaminase AST and Total Bilirubin in blood plasma in comparison with control group. Information analysis of the state of the organ indicates the substantial increase of adaptation and regeneration opportunities of the liver of rats treated with an enzymatic hydrolyzate of Chlorophytum comosum (L.) compared with the liver of rats with experimental toxic liver damage without the use of studied substrate. Histopathological analysis confirmed the simplification of liver damage at application of enzymatic hydrolyzate of Chlorophytum comosum (L.)
Authors and Affiliations
David A. Areshidze, Lyudmila D. Timchenko
Keywords
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