PULSATILE DRUG DELIVERY SYSTEM: AN OVERVIEW
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2013, Vol 3, Issue 2
Abstract
Current research in the field of drug delivery devices, pulsatile drug delivery system is the most interesting time and site-specific system. This system is designed for chronopharmacotherapy. Thus, to mimic the function of living systems and in view of emerging chronotherapeutic approaches, pulsatile delivery, which is meant to release a drug following programmed lag phase, has increasing interest in the recent years. Diseases wherein pulsatile drug delivery systems are promising include asthma, peptic ulcer, cardiovascular diseases, arthritis, attention deficit syndrome in children, and hypercholesterolemia. In pursuit of pulsatile release, various design strategies have been proposed, mainly including time controlling, stimuli induced, externally regulated and multiparticulate formulations. These systems are beneficial for the drugs having chronopharmacological behavior where night time dosing is required and for the drug having high first pass metabolism effect and having specific site of adsorption in gastrointestinal tract. In the present review article, the novel methods of preparing controlled or extended release formulations which can be successfully used in chronotherapy have been mentioned. These techniques also applied for drugs that require modification of drug release, masking of bitter taste, and protection of volatile substances. These technologies have also been found useful for timed- release dosage forms, as timing release tablets, time clock system and delayed-release tablets.
Authors and Affiliations
G. Pragna , B. Shravani , N. G. Raghavendra Rao
Keywords
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