Rapamycin reduces Drosophila longevity under low nutrition
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 8
Abstract
: Rapamycin treatment is considered a pharmacological intervention with the potential to mimic the longevity benefits of dietary manipulations. However, how rapamycin interacts with nutrition is not fully understood. Here we studied the effect of rapamycin on the longevity of Drosophila under a range of dietary conditions. In diets low in nutrients, rapamycin reduced longevity in a dosage-dependent manner. This dosage effect requires some nutrients as rapamycin has no impact on survival under starvation conditions. Under a balanced diet of yeast and sugar, rapamycin had no repeatable beneficial effect on organismal longevity. These results show that the effect of rapamycin on longevity is sensitive to the nutritional environment and it can reduce lifespan when nutrients are limited.
Authors and Affiliations
Eugenia Villa-Cuesta1 * Frances Fan1 , David M. Rand
In vitro antimicrobial evaluation of Anthocephalus cadamba, Butea monosperma, Diospyrous melanoxylon and Ficus glomerata bark extract against certain bacteria
Anthocephalus cadamba, Butea monosperma, Diospyrous melanoxylon and Ficus glomerata bark are used for the preparation of ethnic skin ointments. This ointment in turn is deployed over wounds for healing purposes and to ch...
Hepatoprotective effects of simvastatin on paracetamol -induced hepatic damage in rats
ABSTRACT: This study was designed to investigate the possibility of statins hepatoprotection in paracetamol toxicicity. Paracetamol hepatotoxicity was associated with significant decrease in the serum total&nb...
Determination of HOMA IR cut off value, and efficiency of lipids and lipoprotein ratios as discriminator of insulin resistance in type 2 Diabetes Mellitus patients
Insulin resistance has a central role, not only to predict the future development of type 2 diabetes and incident cardiovascular diseases; as well as can be used as a therapeutic target after hyperglycemia is d...
Candiduria: current scenario
Candida is a commensal of urogenital tract. With the indiscriminate use of antibiotics and wider spectrum of immunocompromised states Candida is gaining importance as pathogenic fungi. The present study was c...
Challenges in management of peripartum cardiomyopathy with diuretic resistance, hypoalbuminemia and hypothyroidism
Background: Peri-partum cardiomyopathy is an idiopathic cardiomyopathy that presents with heart failure secondary to left ventricle systolic dysfunction towards the end of pregnancy or in the months after delivery,...