Role of Copper and Vascular Endothelial Growth Factor (VEGF) on Endometrial Angiogenesis
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2013, Vol 2, Issue 2
Abstract
The formation of new blood vessels is the initialstep in neovascularisation. The first stagein angiogenesis is the activation of endothelialcells. Copper ions stimulate proliferation andimmigration of endothelial cells. It has beenshown that serum copper concentration increasesas the cancer disease progresses andcorrelates with tumour incidence and burden.Copper ions also activate several proangiogenicfactors, e.g., vascular endothelial growth factor,basic fibroblast growth factor, andinterleukin 1. This review concerns a brief introductioninto the basics of blood vessel developmentas well as the regulatory mechanismsof this process. The role of copper ionsin angiogenesis is discussed.
Authors and Affiliations
Yousef Rezaei Chianeh , Pragna Rao
Keywords
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