THE OUTCOME OF FORMULATION AND IN VITRO RELEASE STUDIES OF LEVOTHYROXINE SODIUM TABLETS
Journal Title: Asian J of Pharm Sci & Tech - Year 2011, Vol 1, Issue 1
Abstract
ABSTRACT The present study was to develop immediate release tablet formulation containing 200mg of Levothyroxine Sodium tablets for the treatment of hypothyroidism. Immediate release tablets of Levothyroxine Sodium tablets were prepared using direct compression method. The Fourier transform infra-red analysis was conducted for the surface structure characterization. FTIR spectrum of the formulated immediate release tablets, pure drug and excipients was recorded. The Fourier Transform Infrared Spectroscopy study reveals that there is no interaction between all the excipients and drug. The prepared tablets evaluated in terms of their pre-compression parameters, post-compression parameters and the values are within the limits of pharmacopoeia and other standards. The in vitro release studies concluded that Levothyroxine Sodium, Sodium starch glycollate combination (FLS-9), the drug release satisfactorily when compared with other formulations and also when it is compared with marketed product. The formulations FLS-9 was sufficiently immediate the release of the drug. Key words: Levothyroxine Sodium, Direct compression method and In vitro study.
Authors and Affiliations
A. Arunachalam* and Avijit Mazumder
Keywords
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