THE RELATIONSHIP BETWEEN 1 HOUR GLYCEMIA, DURING ORAL GLUCOSE TOLERANCE TEST AND CARDIOMETABOLIC RISK
Journal Title: Romanian Journal of Diabetes Nutrition and Metabolic Diseases - Year 2012, Vol 19, Issue 1
Abstract
Background Diabetes mellitus is a very common disease, worldwide there are currently over 366 million diabetics. It seems that people with normal glucose tolerance and blood glucose at 1 hour during OGTT ≥200mg% represent an intermediate phenotype of abnormal glucose metabolism, another disturbance of carbohydrate metabolism that is associated with increased cardiometabolic risk. Objectives Starting from these premises, we decided to analyze the subjects with glucose at 1 hour during OGTT ≥200mg%, but with normal values for fasting glucose and 2 hours glucose. In this subgroup of subjects some parameters of CMR were analyzed. We also performed a comparison of this subgroup of subjects with both normal glucose tolerance and 1-hour glucose <200mg%, and with those with abnormal glucose tolerance. Results According to currently used recommendations to diagnose diabetes mellitus, from the 778 people included in this study, 167 (21.5%) had disturbances of carbohydrate metabolism, being classified as patoglycemic and 611 persons (78.5%) had normal values of fasting glucose and 2 hours glucose during OGTT, being considered normoglycemic. From the 611 people who were classified as normal glucose tolerance, based on the currently used criteria for diagnosis of diabetes mellitus, a total of 44 persons (7.2%) had, however, the value of 1-hour glucose during OGTT ≥200mg%, which represents 5.6% of the entire group studied. Conclusions Patients with normal glucose tolerance and glucose ≥200mg% at 1 hour during OGTT represent a new subgroup of impaired glucose tolerance, which requires strict lifestyle advice and possibly pharmacological measures to prevent or delay progression to abnormal glucose tolerance.
Authors and Affiliations
Oana Albai, Romulus Timar
Keywords
Related Articles
- EP ID EP157514
- DOI 10.2478/v10255-012-0004-6
- Views 101
- Downloads 0
FEEDING, BIRTH WEIGHT AND RANK INFLUENCE ON THE RISK OF DIABETES MELLITUS IN CHILDREN
Background: The etiology of type 1 diabetes mellitus supposes the existence of genetic factors, but also environmental ones, of nutritional, fetal (e.g. birth weight) perinatal nature. This study aims at identifying food...
VITAMIN D DEFICIENCY EFFECTS UPON DIABETES MELLITUS AND ITS CARDIOVASCULAR AND RENAL CHRONIC COMPLICATIONS
Vitamin D was proved to have multiple non-skeletal actions, its receptor being expressed by almost every tissue, consequently proper levels being necessary for their optimal functioning. Although biologically inactive, 2...
MONITORING THE PROGRESSION OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH DIABETIC NEPHROPATHY- A PERMANENT CHALLENGE
Aim of study – The monitoring of renal function in 2 statistically comparative groups of patients, first group with diabetic kidney disease (DKD) and the second with non-diabetics patients with the same degree of chronic...
Glucose Variability In Persons With Diabetes Evaluated By Continuous Glucose Monitoring
Blood glucose level is the main indicator of diabetes control. It is related to diabetes evolution and appearance of chronic complications. Daily and/or postprandial glucose fluctuations induce oxidative stress and endot...
SLEEPING WITH THE ENEMY