TRYPSIN AND PROTEIN DENATURATION INHIBITORY ACTIVITY OF LEAF AND ROOT OF JUSTICIA GENDARUSSA
Journal Title: Asian J of Pharm Sci & Tech - Year 2015, Vol 5, Issue 4
Abstract
ABSTRACT Rheumatoid arthritis is a major ailment among autoimmune disorders. A large number of herbal extracts were used for the treatment of various types of rheumatoid disorder. The leaf and root of Justicia gendarussa belonging to Acanthaceae family, commonly known as Nilinirgundi is traditionally used for chronic rheumatism. The present study deals with in-vitro anti-arthritic activity in pharmacological models were studied such as inhibition of protein denaturation and trypsin (proteinase) inhibitory activity. Different fractions and isolated compound from alcoholic extract of leaf and root of J. gendarussa with different concentrations (10, 100, 1000µg/ml ) were studied and results were compared with standard drug Indomethacin. The alcoholic extract of leaf and root of J. gendarussa showed dose dependent activity which was found comparable to that of standard drug Indomethacin. Isolated compound-La of leaf of J. gendarussa inhibited the activity of trypsin with IC50 values 13.43 µg/ml and protein denaturation inhibition at the IC50 value of 24.74 µg/ml as compared to the standard drug Indomethacin. Key words: Justicia gendarussa, Anti-arthritic, Protein denaturation, anti-inflammatory activity, trypsin inhibitory action.
Authors and Affiliations
Patel SS* and Zaveri MN
Keywords
Related Articles
- EP ID EP133661
- DOI -
- Views 152
- Downloads 0
THE PHARMACOLOGICAL IMPORTANCE OF ANTIRRHINUM MAJUS- A REVIEW
ABSTRACT Antirrhinum majus (common snapdragon) is a species of flowering plant belonging to the genus Antirrhinum. It was used traditionally as a diuretic, for treatment of scurvy, liver disorders and tumors. The...
GC-MS EVALUATION OF BIOACTIVE MOLECULES FROM THE METHANOLIC LEAF EXTRACT OF AZADIRACHTA INDICA (A.JUSS).
ABSTRACT Azadirachta indica A.Juss., has a long history of medicinal usage in the treatment of various chronic diseases.The present study was undertaken to explore the potential bioactive components present in th...
AN OVERVIEW OF NEW DRUG DELIVERY SYSTEM: MICROEMULSION
ABSTRACT A microemulsion is a transparent or nearly transparent, quasi-homogeneous, thermodynamically stable mixture of two immiscible liquid stabilized by surfactant (or mixture of surfactant). As pharmaceutical...
IN VITRO CALLOGENESIS FROM BUD AND STEM EXPLANTS OF DRAGON FRUIT (HYLOCEREUS UNDATUS)
ABSTRACT This study was carried out to find out the effect of thidiazuron (TDZ) and 6-benzyl aminopurine (BAP) on callus formation of dragon fruit under in vitro conditions for vegetative propagation. Therefore,...
ANTICANCER EFFECT OF THE MARINE MICRO ALGA, SKELETONEMA COSTATUM (GREVILLE) CLEVE ON HUMAN CERVICAL CANCER CELL LINE
ABSTRACT Marine organisms are rich sources of new, biologically active compounds. Phytoplanktons have traditionally been used as foods. Recently, much attention has been paid to the anticancer activity of Phytopl...