What's new in KYNA? A review of current literature
Journal Title: Current Problems of Psychiatry - Year 2015, Vol 16, Issue 3
Abstract
The present article reviews current research on the role of the metabolites and enzymes of the kynurenine pathway in the pathogenesis, and potential new trends in the therapy, of diseases of the central nervous system. The authors present reports on the regulatory role of the kynurenine pathway in the activity of the immune system and the relationships between the activity of the kynurenine pathway and parameters of inflammation. Also discussed is the role of the kynurenine pathway in the pathomechanisms underlying the development of neurodegenerative diseases, schizophrenia, bipolar disorder and migraine. The article presents research on the role of the kynurenine pathway in the body's response to the action of antipsychotic drugs. An interesting line of research in this area concerns the possibilities of influencing the activity of the kynurenine pathway using synthetic compounds. Another new problem in KYNA research is related to changes in the expression of kynurenine 3-monooxygenase, which may turn out to be a risk factor for neurocognitive deficits in schizophrenic patients. Increased prenatal levels of KYNA may be associated with an increased risk of cognitive deficits in adult life. The kynurenine pathway may also play a regulatory role in the physiology of behavior.
Authors and Affiliations
Nikodem Skoczeń, Emilia Potembska, Marcin Olajossy
Keywords
Related Articles
- EP ID EP153918
- DOI -
- Views 103
- Downloads 0
Understanding humour as a dimension of affective and cognitive competence in patients diagnosed with paranoid schizophrenia
The aim of our study was to analyze the ways of thinking of patients diagnosed with paranoid schizophrenia, and compare this with that of healthy individuals. This was done by ascertaining their reception and interpretat...
Symptoms of anxiety and depression in patients with relapsing-remitting multiple sclerosis
Aim. The aim of this article was to present the emotional functioning of patients facing the diagnosis of the chronic disease Multiple Sclerosis. Methods. The instruments used in the study included a socio-demographic q...
Psychiatry in the Face of Ethical Challenges. A report from the “Focusing on Ethics” Session of the XVI World Congress of Psychiatry in Madrid
Ethical issues play an important role in current psychiatric practice. These issues are the subject of many conferences and publications, and, predictably, they were brought up again during the XVI World Congress of Psyc...
Potrzeby emocjonalne a korzystanie z portalu społecznościowego przez młodzież
Celem pracy było udzielenie odpowiedzi na pytanie: czy i jakie zależności występują między potrzebami emocjonalnymi a aktywnością wykazywaną przez młodzież na portalu Nasza Klasa? Badaniami objęto grupę 279 uczniów gim...
Sfery konfliktów małżeńskich w sytuacji rozłąki migracyjnej rodziny z powodu pracy za granicą
Celem artykułu było ukazanie tych sfer życia rodzinnego małżonków doświadczających rozłąki migracyjnej z powodu pracy za-robkowej za granicą, które mają istotne znaczenie dla jakości relacji małżeńskiej oraz postrzegania...