NEPHROPROTECTIVE ACTIVITY OF ASPARAGUS RACEMOSUS AGAINST CISPLATIN-INDUCED NEPHROTOXICITY AND RENAL DYSFUNCTION IN EXPERIMENTAL RATS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2018, Vol 11, Issue 12
Abstract
Objective: The current study was designed to evaluate the protective effect of standardized hydroalcoholic extract of Asparagus racemosus (AR) against cisplatin (CP)-induced nephrotoxicity in Wistar rats.Methods: AR extract was administered orally at three dose levels (100, 200, and 400 mg/kg). Vitamin E (250 mg/kg) was used as a standard nephroprotective agent. The kidney function test (estimation of serum creatinine, albumin, and blood urea nitrogen [BUN]), oxidative stress study (estimation of superoxide dismutase and malondialdehyde [MDA] activity), and histological examination of kidneys were conducted.Results: The efficacy of AR was compared with CP-treated group. Serum creatinine and BUN were significantly (p<0.001) elevated in CP-treated group compared to control group. Hydroalcoholic extract of AR (100, 200, and 400 mg/kg) and Vitamin E (250 mg/kg) significantly (p<0.001) decreased the serum creatinine and BUN levels. CP exhibited significant (p<0.001) decrease in albumin when compared to control. Significant (p<0.001) increase in the serum albumin level was found in extract-treated group compared to CP group. Significant (p<0.001) decrease in activity of superoxide dismutase (SOD) was observed in the CP group as compared to control. AR (100 and 200 mg/kg) significantly (p<0.01) increased SOD levels. AR (400 mg/kg) significantly (p<0.001) increased SOD levels. AR (100, 200, and 400 mg/kg) significantly (p<0.001) decreased MDA levels as compared to CP group. Histopathological examination of the kidneys showed that AR markedly ameliorated CP-induced renal tubular necrosis. Extract was found effective at all doses, although high dose (400 mg/kg) was found to be more effective and comparable with standard group (Vitamin E 250 mg/kg).Conclusion: The present investigation revealed that AR resulted in dose-dependent attenuation of CP-induced renal damage in rats.
Authors and Affiliations
Yadav Av, Upasani Cd
Keywords
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- EP ID EP605198
- DOI 10.22159/ajpcr.2018.v11i12.28132
- Views 111
- Downloads 0
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