Nephroprotective activity of heliotropium indicum in rifampicin induced nephrotoxicity rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2019, Vol 8, Issue 2
Abstract
The nephroprotective effect of whole plant of ethanolic extract of Heliotropium indicum was confirmed by our study. In Rifampicin treated group urea, uric acid and creatinine levels are increased in serum and urine whereas decreased total protein levels. In the present study, the whole plant of ethanolic extract of Heliotropium indicum significantly reduced the toxicant elevated levels of above mentioned parameters and increased in the levels of protein. Hence at this point it is concluded that the extract of Heliotropium indicum offers nephroprotection. Based on improvement in serum and urine marker levels, histopathological studies, level of antioxidant enzymes and presence of phytoconstituents, it is concluded that the ethnolic extract of Heliotropium indicum possesses nephron protective activity and thus supports the traditional application of the same under the light of modern science.
Authors and Affiliations
N. Nagamalleswari
Keywords
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