Neurogenic inflammation markers in children with vertebrobasilar arterial system syndrome and recurrent bronchitis
Journal Title: Здоров`я дитини - Year 2017, Vol 12, Issue 4
Abstract
Background. The study of the neurogenic maintenance characteristics of the recurrent bronchitis (RB) course in children with the vertebrobasilar arterial system syndrome (VBASS) by studying the levels of the final stable metabolites of nitric oxide (FSM NO), substance P and vasoactive intestinal peptide (VIP) will make it possible to establish important elements of the frequent diseases respiratory tract pathogenesis. Materials and methods. Sixty children aged 7 to 11 years old with anamnesis of RB were examined. Two observation groups were formed (30 patients in each): 1) children with RB in the period of somatic well-being and VBASS; 2) children with RB in the period of somatic well-being without VBASS. Results. In children with RB, who have VBASS, as compared to the children without VBASS, we have detected an increase in FSM NO serum levels (by 36.7 %, p < 0.05) (odds ratio (OR) = 6.50, 95% confidence interval (CI) 1.82–23.21, p < 0.05), substance P (by 40.0 %, p < 0.05) (OR = 6.00, 95% CI 1.89–19.04, p < 0.05), a decrease in concentration of VIP (by 26.7 %, p < 0.05) (OR = 3.05, 95% CI 1.05–8.84, p < 0.05) statistically significantly more often. Conclusions. In children with RB and VBASS, during the period of somatic well-being, the focus of the neurogenic inflammatory process takes place, which is accompanied by an autonomous neuronal processes imbalance and predisposition to recurrent bronchopulmonary pathology.
Authors and Affiliations
L. S. Ovcharenko, T. V. Slutskaya
Keywords
Related Articles
- EP ID EP213391
- DOI 10.22141/2224-0551.12.4.2017.107627
- Views 95
- Downloads 0
Drug limitation of the availability of iron ions for pathogenic bacteria (part 1)
Most bacteria are microorganisms that require iron to support their vital functions. Iron is the most important macroelement of microorganisms acting as an electron carrier and cofactor of DNA and RNA synthesis. Most bac...
Modern Methods of Mucoactive Therapy for Respiratory Diseases in Children
The article deals with the issues of rational and optimal mucolytic therapy for respiratory diseases in children. The approaches to the choice of therapy are considered based on the pathogenetic mechanisms of disorders o...
Biliary Dysfunction in Children with Iron Deficiency
Background. Functional disorders of the biliary tract (FDBT) remain a topical problem of pediatric gastroenterology due to the high incidence and progressive course with formation of chronic cholecystitis and cholelithia...
Herpes virus 6 hepatitis in an infant
The article presents a clinical observation of 1-year old child diagnosed with hepatitis in the structure of reactivated form of herpes virus type 6 infection. There was a significant increase in transaminase level with...
The content of antimicrobial peptides in young children with acute bronchitis depending on the etiological factor
We have investigated the level of antimicrobial peptides in the blood serum of 46 young children with acute bronchitis depending on the etiological factor. It was found that the development of severe bronchitis in 74.3 %...