Neuroleptic Malignant Syndrome (Case Presentation)
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 6
Abstract
Neuroleptic malignant syndrome (NMS) is an uncommon but potentially fatal adverse effect of neuroleptic drugs. It is commonly characterized by muscular rigidity, fever, altered mental status, and autonomic dysfunction. Its pathophysiology is not clearly understood, but the blockade of dopamine receptors appears to be the central mechanism. The presented case is for a patient who suffered from severe depression and was getting worse despite being on treatment. Being on many neuroleptic medications of high dosages and presenting with agitation and being combative against the medical staff in the Emergency Department, the patient got exposed to high doses of antipsychoticmedications. The patient condition got complicated with NMS and multi-organ failure due to undiagnosed severe Aortic stenosis and cardiogenic shock.
Authors and Affiliations
Terad Talmesany M. D
Keywords
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