Neuroprotective Effects of High Density Lipoproteins (APOE) and Neurodegenerative Disorders Related to Apoe-Hdl
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 8
Abstract
There are a number of potential mechanisms through which HDL could act to protect neural function. Apolipoproteins E is the most abundant apolipoproteins in the brain. ApoE-HDL and cholesterol are synthesized mainly by de novo synthesis in astrocytes. Three major functions of astrocyte-derived ApoE-containing lipoproteins includes transfer of phospholipids and cholesterol via ATP-binding cassette (ABC) transporters such as ABCA1 and ABCG1,interaction with the LDLR super family of proteins located on the surface of neurons to facilitate axonal growth and neuronal survival and interaction with the LRP1-dependent cellular uptake pathway in the deposition of amyloid plaques. Cholesterol is a very important membrane lipid to keep function and survival of neurons in the brain. The brain contains about 20% of whole body cholesterol. Brain cholesterol is involved in axonal elongation, dendrite differentiation, synapse development and synapse formation, long-term potentiation, Learning and memory Neuroprotective effects of ApoE-HDL in the brain includes suppression of Aβ production by decreasing cellular cholesterol, can directly bind excess Aβ and thereby inhibit cholesterol oligomerisation, remove Aβ that accumulates in the vessel wall during the course of VD, decrease oxidative stress and thereby indirectly decrease Aβ production, can act on astrocytes to attenuate a local inflammatory reaction, accelerates maturation of synapses and maintain of synaptic plasticity. Disturbances in cholesterol homeostasis have been associated to the onset and the development of several neurological disorders such as AD, NPC and HD disease.
Authors and Affiliations
Demeke Ashencho
Keywords
Related Articles
- EP ID EP374324
- DOI -
- Views 88
- Downloads 0
Risk Factors for Obesity and Overfat among Primary School Children in Mashonaland West Province, Zimbabwe
Background: childhood obesity is a major and emerging public health problem in developed and developing countries respectively. Associated risk factors are not well established in developing countries such as Zimbabwe an...
A Rare Case Report on T- Cell Lymphoid Blast Crisis of CML with an Unusual Presentation
T-cell lymphoid blast crisis is a very rare presentation in chronic myelogenous leukaemia (CML). Considering its rare entity, herein we report a case of T-cell lymphoid blast crisis of CMLin a 27 year old female who pres...
Clinicopathological Profile of Patients with Chronic Leukaemia
Leukaemias are the malignancies arising from unregulated clonal proliferation of haematopoietic stem cells. The present work is an attempt to study the frequency of chronic leukaemia, to analyse and classify and to corre...
Management of Ectopically Erupting Maxillary Central Incisor Using Removable Appliance
Ectopic eruption is a deviation from normal eruption pattern. The occurrence of ectopic eruption is most commonly associated with maxillary incisors. The normal eruption, position and morphology of these teeth are crucia...
Lactic Acid Bacteria Growth in Indian Fermented Foods Available in Delhi Markets
Probiotic as functional foods is gaining popularity in India. They are food which provides special beneficial effect to the host along with the basic nutrition. Probiotic organism grows in products prepared by spontaneou...