Neuroprotective profile of mulberry leaf extract in focal cerebral ischemia model in rats
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2016, Vol 4, Issue 3
Abstract
The cerebral ischemia causes severe degree of oxidative stress as a result of reperfusion injury. An attempt has been made to analyze the preventive and curative potential of mulberry leaf extract, in focal cerebral ischemia model in rat, as it is rich source of novel chemicals possessing antioxidant and neuroprotective properties. The aqueous extract (MLE-AR-14) pre-treatment one hour prior to ischemia significantly (65%) prevented the ischemic cerebral damage. It also tended to revert the behavioral deficit caused due to brain damage. The biochemical markers of oxidative stress MDA and GSH were also significantly altered towards basal levels. The most important and exciting finding is the effectiveness of MLE-AR-14 administration after six hours post cerebral injury. The extract at a dose of 100 mg/kg p.o. caused reduction in cerebral infarct by 54% indicating its curative potential in cerebral stroke. The oxidative end product MDA was reduced by 42 % and the level of GSH was elevated by 54% on post-treatment. Thus, it seems that MLE-AR-14 has a potent neuroprotective profile and also has modulatory effect on cellular and biomolecular processes in preventing redox status to arrest apoptotic and necrotic processes underlying focal cerebral ischemia, as evidenced by histological parameters. The post-ischemic efficacy of the extract suggests that it may be clinically exploited in cerebral stroke.
Authors and Affiliations
Sheeba Saji Samuel, Abhishek Desai, R Raghubir and Venkatesh Kumar R
Keywords
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