Neuropsychological and Related Clinical Features Associated with Complex Regional Pain Syndrome: A Latent Class Analysis
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 18, Issue 12
Abstract
Aim: The current research examined neuropsychological and key features related to Geschwind-Behan-Galaburda (GBG) model (i.e., non-right handedness, learning problems, autoimmune disease) in patients with Chronic Regional Pain Syndrome (CRPS). Methods: A large sample of patients with CRPS (n=509) were evaluated with a neuropsychological protocol that assessed executive control, language/ lexical retrieval, and declarative memory. A portion of our sample was assessed with the modified Oldfield-Edinburgh questionnaire (n= 262) surveyed handedness, learning problems, and autoimmune disease was obtained on a portion of patients. Results: Latent Class Analysis identified four neuropsychological classes: patients with moderate cognitive impairment (n= 44), patients with elements of an amnestic syndrome (n= 93), patients with intact but low average/ average neuropsychological test performance (n= 191), and patients with average/ high average neuropsychological test performance (n= 181). Elements of dysexecutive impairment were obtained in some groups. A minority, but statistically significant number of patients presented with mixed/ non-right handedness (26.30%); learning disabilities/ related problems (18.40%); and autoimmune disease (23.50; P< .001, all analyses). While intact neuropsychological performance was generally found in this large sample of patients with CRPS patients, elements of mild dysexecutive and amnestic impairment were observed in a portion of patients. Conclusion: Neuropsychological impairment is present in a minority number of patients. The statistically significant incidence of non-right handedness, learning problems, and autoimmune medical disorders among a subset of patients is consistent with elements of the GBG model. Summary: These data suggest the presence of mild neuropsychological deficits in some patients along with the possibility for anomalous brain development, suggesting a possible predisposition for CRPS in some patients.
Authors and Affiliations
David J. Libon, Joel Eppig, Kirsten Erwin, Christine Annibali, Lynn Durmala, Aaron Bloch, Jacqueline Donohue, Rodney Swenson, Guillermo M. Alexander, Enrique Aradillas, B. Lee Peterlin, Robert J. Schwartzman
Keywords
Related Articles
- EP ID EP341119
- DOI 10.9734/BJMMR/2016/29713
- Views 97
- Downloads 0
Supernumerary Molars: A Rare Finding
Panoramic radiographs of a female patients aged twenty one years without any associated syndromic or systemic medical history, revealed the presence of the two supernumerary molars, right upper and left lower fourth mola...
Proton Pump Inhibitors and Corticosteroids as Synergistic Risk Factors for Candida Esophagitis
Introduction: Inhaled & systemic steroids are one of the well-documented risks factors for Candida esophagitis. However, the role of gastric acid suppression remains controversial. Methods: We conducted a retrospective...
Effect of Methanolic Extract of Passiflora foetida on Glucose Kinetics in Alloxan-induced Diabetic Mice
Background: This study investigated the hypoglycemic potential of methanolic extract of Passiflora foetida (PF) in alloxan-induced diabetic albino mice. Diabetes is a metabolic disease characterized with high blood sugar...
Family Food Choices Relate to Nutritional Behavior in Adult Patients with Type 1 Diabetes: Possible Implications on Metabolic Control
This study compared the levels of calories and macronutrients ingested by patients with type 1 diabetes and their relatives. This is a cross-sectional study that evaluated dietary intake (24-hour Food Record), nutritiona...
Knowledge and Beliefs Regarding Contraception among Married Women in Gwagwalada, Abuja, Nigeria
Inadequate knowledge and misconceptions on contraception has sustained the low prevalence of contraceptive use in Nigeria over the years. Aim: This study aims to assess the knowledge and beliefs regarding contraception...