Neurotrophic effects of turmeric on the memory of the mouse using the Morris water maze test
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 5
Abstract
Background: Turmeric is a yellow-orange spice found mainly in India and other parts of Asia and South America, and is widely used for its medicinal properties. Curcumin, the main part of the turmeric rhizome, may have properties that can improve the memory of mice in a step-through latency test. Aims and Objectives: In this study, turmeric was utilized to determine its effect on the memory of mice using the Morris water maze (MWM) to assess spatial memory of rodents. Materials and Methods: Determination of the effect of intake of turmeric powder in sterile olive oil was observed, as well as the effects of the different doses of administration (control, 5 mg/kg, 15 mg/kg, and 45 mg/kg) of turmeric based on the performance of mice in the MWM. Further investigation was done by analyzing the apoptotic count on the hippocampal area of the mouse brain. Results: No significant effects were detected on the analysis of both the pre-treatment and posttreatment data on the MWM test, which may imply that the observed downhill trend may be due to chance alone. On the other hand, the significant difference brought about by the treatments of 5 mg/kg, 15 mg/kg, and 45 mg/kg doses on the comparison against the control on the histological analysis by counting the apoptotic cells on the mouse hippocampus was observed. Conclusion: The effect of memory improvement of turmeric administration is, therefore, due to the preventive effect of the turmeric against oxidative stress and its ability to inhibit the apoptosis, or programmed cell death, of neurons. Thus, turmeric has the ability to protect brain cells from deterioration and maybe a potential neuroprotective agent if studied further.
Authors and Affiliations
Ma. Josephine Eliza Amor P Sarona, Michael B Ples, Rodel Jonathan S Vitor II
Keywords
Related Articles
- EP ID EP489547
- DOI 10.5455/njppp.2018.8.1039116012018
- Views 104
- Downloads 0
Effect of high and low intensities of aerobic training on rate pressure product
Background: Aerobic exercise reduces body fat and improves weight control, increases high-density lipoprotein and Vo2max (maximal oxygen consumption), decreases resting heart rate (RHR) and systolic blood pressure (BP),...
High-resolution manometric features of achalasia of the cardia
Background: Achalasia of the cardia is a common esophageal motility disorder. High-resolution manometry is the gold standard for the diagnosis of achalasia. The body of the esophagus and the lower esophageal sphincter (L...
Influence of athletic training on hematological parameters in runners: A cross-sectional study
Background: Athletics is one of the purest of all sports, relying solely on the strengths of the human body rather than technological implements to improve performances. Alterations of the red blood cell (RBC) sys...
A comparative study of lipid profile, body mass index, and waist circumference among Type 2 diabetes mellitus patients with poor and good metabolic control and normal age-matched control group
Background: Prevalence of dyslipidemia is very common in Type 2 diabetes mellitus (DM), and lipid abnormalities are likely to play an important role in the development of the atherosclerotic vascular disease. Type 2 diab...
Alterations of lipid profile in subclinical hypothyroidism
Background: Thyroid hormones regulate a wide array of metabolic parameters and exert effects virtually on every organ system. Subclinical hypothyroidism is more common than overt hypothyroidism, and an apparently asympto...