Nevirapine induced Stevens Johnson Syndrome
Journal Title: Journal of Pharmacovigilance and Drug Research - Year 2020, Vol 1, Issue 20201206
Abstract
A 56-year-old male patient presented with a complaint of lesions all over the body with a burning sensation for 4 days. He was on an ART regimen, containing zidovudine, lamivudine, and efavirenz combination for 4 years. But patient accidentally started nevirapine and after 10 days he developed maculopapular lesions which were diagnosed as SJS syndrome. There was a history of rash with nevirapine when ART was started initially in 2012. This incident of an adverse event could be assigned a term "probable" according to the WHO-UMC scale for causality assessment as the re-challenge was found positive. Severe and life-threatening SJS is more common with nevirapine than with other NNRTIs. Physicians and patients must be aware of this adverse effect on early diagnosis and treatment.
Authors and Affiliations
Himani Prajapati1, Neetu Bala2*, Dinesh Kansal2
Keywords
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- DOI 10.5281/zenodo.4299042
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