New Epigenetic Pathway of Carcinogenesis Associated with Helicobacter Pylori
Journal Title: Гастроентерологія - Year 2015, Vol 3, Issue 57
Abstract
New epigenetic pathway of Helicobacter pylori carcinogenesis is initiated by trigger oncogenes of the bacteria. The main mechanism of carcinogenesis — tyrosine kinase phosphorylation with excessive activation of tyrosine kinases and activation of MAPK ERK signaling pathways of normal cell proliferation, that disturbs normal proliferation and leads to uncontrolled cell growth, transformation and, as a result, to tumorigenesis.
Authors and Affiliations
S. I. Klymniuk, E. M. Kovanova, M. S. Tvorko
Keywords
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