New Hypoglycaemic Drugs for the Treatment of Diabetes Mellitus and Its Complications: The Future is coming.
Journal Title: Open Access Journal of Urology & Nephrology - Year 2019, Vol 4, Issue 1
Abstract
Diabetes mellitus (DM) has become a growing epidemic over the last few decades. The International Diabetes Federation (IDF) estimates that more than 640 million people will be affected by this condition by 2040. Although the incidence of some of the cardio-vascular complications of DM seems to have shown a decrease over the last years, DM continues to be the main cause of kidney disease, which will require renal replacement therapy (RRT). Many different studies have tried to demonstrate, not always effectively, that the application of clinical practice guidelines and consensus documents may help to stop the onset and progression of the vascular and renal complications of DM. Numerous molecules have also emerged in recent years to improve both the management of DM as well as the onset of micro and macro vascular complications. In this review, we will provide a summary of the metabolic, vascular and renal effects of DPP-4 inhibitors, Glucagon-likePeptide 1 Receptor agonists (GLP-1a) and sodium-glucose co-transporter inhibitors (SGLT2i), especially in patients with diabetic kidney disease with decreased renal function. These new molecules seem to open favorable perspectives in the integrated and multi factorial care of the DM patients.
Authors and Affiliations
Alberto Martínez-Castelao
Keywords
Related Articles
- EP ID EP521177
- DOI -
- Views 65
- Downloads 0
Penile Fracture by Dog Bite in Children: A Case Report
We report a case of ten years old boy with external genitalia trauma by dog bite. The boy was running when he hit the neighbor’s unrestrained dog which was sleeping outdoors. The child presented with urinary retention wi...
Decrease in Quality of Life and Functional Assessment in Elder Patients with End-Stage Renal Disease after Two Years of Hemodialysis Therapy
Introduction: Hemodialysis improves survival rates of Chronic Kidney Disease (CKD) patients but not Quality of Life (QoL) which decreases in a more aggressive way in the elderly population. We describe the reduction and...
Proteinuria as a Marker of Chronic Kidney Disease: A Single Centre Single Day Screening Experience for 9 Years in Varanasi
Introduction: Chronic kidney disease is an asymptomatic devastating medical illness which often results in delayed recognition with direct social and economic consequences for the patients, their families and the country...
Does it need to Take Digitally Targeted Biopsies Additionally to TRUS Guided 12- Core Systematic Prostate Biopsies? A Single Center Prospective Clinical Study
Purpose: To investigate whether digitally targeted additional biopsies enhance the detection rate of standard 12-core TRUS guided systematic biopsies. Methods: A total of 119 patients who either have a PSA level greater...
Future Perspectives, Education and Training of Flexible Ureteroscopy for Urolithiasis-Some Personal Views
Urolithiasis is a common problem affecting patients irrespective of age and gender. Importantly, it is a recurrent disease with a lifetime risk of recurrencureteroscopygh. In the present days, almost all urinary tract st...