NEW INSIGHTS INTO MOLECULAR TARGETS FOR DEPRESSION
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 12
Abstract
Major depressive disorder is a heritable neuropsychiatric syndrome characterized by relatively subtle cellular and molecular alterations localized to a complex network of neural substrates. Various forms of psychotherapy, pharmacotherapy, and electroconvulsive therapy (ECT) are currently the most commonly used antidepressant treatments. Despite adequate care with currently available treatments, up to 70% of depressed patients have residual symptoms, and, even with more aggressive therapies, 20% or more may show only a limited response. The need for newer compounds to treat depression is still an ever growing concern due to the enormous societal and famifications of depression. This review covers all the monoaminergic (SSRI/5-HT1A antagonists, SSRI/5-HT2C antagonists, SSRI/alpha-2 adrenergic antagonists, triple reuptake inhibitors, dopamine agonists, targeting GABA) and beyond monoaminergic strategies including corticotropin-releasing factor (CRF)-1 receptor antagonists, Inhibition of glucocorticoid function, substance P (Nk-1) antagonists, MCH1 receptor antagonists, Gal3 receptor antagonists, arginine vasopressin as the potential novel targets for depression.. However, To be the most successful novel target it shouldn’t only demonstrate preclinical antidepressant like effects, but also target the unmet clinical needs and lead to long-term disease modification.
Authors and Affiliations
Hiren Mehta , Prakash Thakkar, Vishal Vekariya, Indermeet Singh
Keywords
Related Articles
- EP ID EP119535
- DOI -
- Views 100
- Downloads 0
PHYTOCHEMICALS SCREENING BY FTIR SPECTROSCOPY AND ANTIMICROBIAL ACTIVITY OF DIFFERENT SOLVENT FRACTIONS FROM MURRAYA KOENIGII L. SHOOTS
Murraya koenigii L. (M.koenigii) is a spice herb and a medicinal plant, well known for its numerous biological activities. In the present research work, different solvent fractions from shoots of M.koenigii were analyzed...
A REVIEW OF WORK DONE ON FLOATING DRUG DELIVERY SYSTEM CONTAINING CARDIO VASCULAR DRUGS
In the recent years, scientific and technological advancements have been made in the research and development of novel drug delivery systems by overcoming physiological troubles such as short gastric residence times and...
A RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF FEBUXOSTAT IN BULK AND PHARMACEUTICAL DOSAGE FORMS
A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of Febuxostat in pharmaceutical dosage form. Isocratic elution at a flow rate of 1.0 mL min -1 was employed on...
HPLC ANALYSIS OF EXTRACT OF IN VIVO MEDICINALLY IMPORTANT CLIMBER CISSUS QUADRANGULARIS L. (HADJOD)
Cissus qudrangularis L. (Hadjod) belongs to family Vitaceae is an indigenous medicinal plant of India. It has been prescribed in ancient Ayurvedic texts as a general tonic especially for the fractured patient. The...
STUDIES ON EFFECT OF RELATIVE HUMIDITY ON FUNGAL GROWTH AND DETERIORATION OF TOTAL ALKALOIDS IN FRESH AND MARKET ROOTS OF DRUG URARIA PICTA DC.
In the present study, 26 fungi have been isolated from the fresh and market roots of drug Uraria picta Dc. Fungi F. solani with 31.5% observed in highest percentage incidence from genuine samples but in the market sample...