New oil modified acrylic polymer for pH sensitive drug release: Experimental results and statistical analysis

Apply

New oil modified acrylic polymer for pH sensitive drug release: Experimental results and statistical analysis

Journal Title: JOURNAL OF ADVANCES IN NATURAL SCIENCES - Year 2015, Vol 3, Issue 1

Abstract

We report results of an experimental study, complemented by detailed statistical analysis of the experimental data, on the development of a more effective control method of drug delivery using a pH sensitive acrylic polymer. New copolymers based on acrylic acid and fatty acid are constructed from dodecyl castor oil and a tercopolymer based on methyl methacrylate, acrylic acid and acryl amide were prepared using this new approach. Water swelling characteristics of fatty acid, acrylic acid copolymer and tercopolymer respectively in acid and alkali solutions have been studied by a step-change method. The antibiotic drug cephalosporin and paracetamol have also been incorporated into the polymer blend through dissolution with the release of the antibiotic drug being evaluated in bacterial stain media and buffer solution. Our results show that the rate of release of paracetamol getss affected by the pH factor and also by the nature of polymer blend. Our experimental data have later been statistically analyzed to quantify the precise nature of polymer decay rates on the pH density of the relevant polymer solvents. The time evolution of the polymer decay rates indicate a marked transition from a linear to a strictly non-linear regime depending on the whether the chosen sample is a general copolymer (linear) or a tercopolymer (non-linear). Non-linear data extrapolation techniques have been used to make probabilistic predictions about the variation in weight percentages of retained polymers at all future times, thereby quantifying the degree of efficacy of the new method of drug delivery.

Authors and Affiliations

Amit Kumar Chattopadhyay, Nimai Panja

Keywords

Control release pH factor copolymer tercopolymer least square fit non-linear extrapolation drug delivery

Comparison of Chemical Composition and Toxicity of Essential Oils from Lemongrass (Cymbopogon Citratus) Extracted with Microwave-Assisted Hydrodistillation (MAH) and Conventional Hydrodistillation (HD) Methods

The demand of essential oil in current industry has increased due to its bioactive compound that shows various therapeutic effects. Therefore, the qualities of essential oil mainly depend on its constituents. This study...

EP ID EP654894
DOI 10.24297/jns.v3i1.5013
Views 180
Downloads 0