Nitric Oxide and Antioxidant Enzymes in Venous and Cord Blood of Late Preterm and Term Omani Mothers
Journal Title: Sultan Qaboos University Medical Journal - Year 2012, Vol 12, Issue 3
Abstract
Objectives: Tis study assessed the role of oxidative stress in parturition in Omani mothers following growing reports that late preterm neonates were at greater risk than term neonates of perinatal death. Methods: Venous blood samples were collected during labour, and cord (neonatal) blood samples were taken after childbirth in late preterm and term from women at Sultan Qaboos University Hospital, Oman. Plasma nitric oxide (NO) concentrations, erythrocyte catalase (CAT). Erythrocyte glutathione peroxidase (GPx) activities were measured using spectrophotometric methods. Results: When compared with term mothers, late preterm mothers had markedly higher NO concentrations (µmol/L) 17.1 ± 3.3 versus 11.0 ± 5.5 (P <0.0001), and lower GPx values (U/g Hb) 94.1 ± 12.9 versus 110.4 ± 12.3 (P <0.0001). Late preterm mothers were signifcantly younger (P = 0.027) than term mothers and had neonates that weighed signifcantly less (P <0.0001) than term neonates. GPx activity was signifcantly reduced (P = 0.001) in late preterm neonates as compared to term neonates. CAT showed no change in activity in any comparison. Conclusion: Distinctly higher values of NO and lower GPx activity were found in late preterm mothers relative to term mothers; also, lower GPx in late preterm neonates relative to term neonates suggested a pro-oxidant-antioxidant imbalance due to the greater oxidative burden in late preterm parturition.
Authors and Affiliations
Clifford Abiaka| Department of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman, Lovina Machado| Department of Obstetrics & Gynaecology, Sultan Qaboos University Hospital, Muscat, Oman
Keywords
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