Nitric oxide levels in periodontitis with relation to obesity
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2016, Vol 3, Issue 1
Abstract
Background: There is growing evidence that nitric oxide (NO) is critically involved in obesity and its clinical consequences like cardiovascular disease, hypertension and diabetes. However the role of nitric oxide in oral condition like periodontitis in relation to obesity is not clearly understood. Hence we have attempted to elucidate role of serum and salivary nitric oxide in obese and non-obese periodontitis patients. Method: We investigated 100periodontitis patients; out of which 50 were obese (Group C) and 50 were non-obese patients (Group B) along with 50 normal weight, age matched healthy controls (Group A). Various dental and clinical parameters as well as body measurements were assessed. Results: Group B and Group C showed a marked increase (P <0.001) in clinical attachment loss and probing depth when they are compared with Group A. Group B and Group C patients are also compared for body mass index and waist circumference with Group A.BMI and WC was found to be non significant in Group B when compared with Group A. Group C patients exhibited a highly significant increase in BMI and WC when compared with Group A. Group C patients also showed a highly significant increase in BMI and WC when compared with Group B. The study also documented a significant increase in serum & salivary nitric oxide levels in Group B and C when compared to Group A. (P<0.001).Obese periodontitis patients (Group C) revealed highly significant increase (P <0.001) in nitric oxide levels than non-obese periodontitis patients (Group B). Conclusion: Obesity can be considered as an important contributing factor in enhancing the severity of periodontitis as well as nitric oxide production in these patients.
Authors and Affiliations
Pradnya Shree Dhotre, Rajashree Basawraj Bhogade, Abdul Kayyum Shaikh
Keywords
Related Articles
- EP ID EP242112
- DOI -
- Views 94
- Downloads 0
Comparative study of oxidative stress in type 2 diabetes mellitus with in vitro oxidative stress using ferrous ascorbate as pro-oxidant
Diabetes mellitus is a chronic endocrine disorder associated with a multitude of microvascular and macrovascular complications The imbalance between the productions of free radicals plays a prominent role in the developm...
Serum cholesterol profile in children with celiac disease and effect of gluten free diet
Background: various researchers have shown association of celiac disease with altered lipid profile. We studied serum cholesterol levels in patient with celiac disease and effect of gluten free diet on it. This study aim...
Effect of adenosine deaminase activity on lipid profile in patients of type 2 diabetes mellitus
Background: Type 2 diabetes mellitus is a worldwide endemic disease. Dyslipidemia is also a frequent disorder associated with diabetic patients. The present study is an attempt to link that elevated levels of adenosine d...
Assessment of Lipoprotein (a) and Lipid Profile Pattern in patients of Pre-Eclampsia
Introduction: Preeclampsia is a hypertensive disorder of pregnancy characterized by endothelial dysfunction. The present study was planned to assess and compare the levels of serum Lipoprotein (a) and lipid profile in pr...
Gender specific utility of lipid ratios and its correlation with systemic inflammation in acute myocardial infarction (AMI) patients with type 2 diabetes mellitus – A hospital based study
Objective To evaluate Gender specific alterations in the levels of serum lipid profile parameters Total Cholesterol TC Triglycerides TG Low density lipoprotein Cholesterol LDLC High density lipoprotein Cholesterol HDLC n...