Non Candida albicans Candida (NCAC) of oral cavity in head and neck cancer patients under cancer therapy: Prevalance, species identification and antimycotic sensitivity pattern
Journal Title: IP International Journal of Medical Microbiology and Tropical Diseases - Year 2018, Vol 4, Issue 2
Abstract
Introduction Cancer patients remain at risk for developing serious infections due to oropharyngeal Candida colonisation as the incidence of Candidiasis continues to rise after chemotherapy CT Radiochemotherapy RCT or Radiotherapy RT for head and neck cancer So accurate and rapid identification of candida species is very important in clinical laboratoryObjective To study the prevalance species identification and antimycotic sensitivity pattern of Candida spp of oral cavity in patients of head amp neck cancer undergoing chemotherapy CT amp Radiochemotherapy RCT and compare with control groupMaterials and Methods This is prospective cross sectional and case control analysis including 110 patient in study group chemotherapy CT55 patient Radiochemotherapy RCT55 patients and 50 healthy individuals as control Candida isolates identified by standrad methods using morphological biochemical amp chromogenic property of different Candida spp and antimycotic sensitivity applied by disc diffusion methodResults Prevalence of Candida spp colonization seen in 50 patients of study and 20 in control group p value 0004 patients on RCT 636 have higher prevelance as compare to CT 364 p 0007 C tropicalis was most common 38 species followed by C albicans 11 amp C glabrata 11 most of isolates were sensitive to Amphotericin B and Nystatin and least sensitive to FluconazoleConclusion High prevalence of Candidal carriage and the species variation and changing pattern of antifungal susceptibility of Candida spp in patients undergoing chemotherapy and radiation therapy require isolation and speciation of the causative Candida sp and prophylaxis is needed to prevent infection among these patientsKeywords Candida species Non Candida albicans Candida NCAC Oral cavity Head amp neck cancer Radiochemotherapy
Authors and Affiliations
Priyanka Soni, Laxman Kumar Soni, Shashi Kala Verma
Keywords
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- EP ID EP485850
- DOI 10.18231/2581-4761.2018.0019
- Views 83
- Downloads 0
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