Non-Hodgkin lymphomas – T cell type: Histomorphology and immunohistochemistry
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 4
Abstract
Introduction NonHodgkin lymphomas NHL comprise a wide variety of neoplasms and are subdivided into two main categories of low grade and high grade lymphomas The major subtypes among T cell lymphomas are Peripheral T cell lymphomas Not otherwise specified Anaplastic Large cell lymphoma ALK positive Angioimmunoblastic Tcell lymphoma T lymphoblastic leukemialymphoma and Extranodal NKT cell lymphoma nasal type In this study the histomorphological diagnostic features and the adjunct immunohistochemical expression of various markers are studied in a tertiary care centre in South IndiaMaterials and Methods Patients with lymphadenopathy over a period of two years were included in the study Lymph nodes excised from these patients were routinely processed and examined After initial examination with HE stain appropriate special stains like Reticulin stain Periodic Acid Schiff stain and ZiehlNeelsen stains are performed along with the specific Immunohistochemical markersResults A total of 30 cases were classified as NonHodgkin Lymphoma high grade T cell type Peripheral T cell lymphomasNOS is found to be the most common tumors accounting for 40 of all high grade T cell NHLs The next common tumor was Anaplastic Large Cell Lymphoma ALK positive with 36 of cases T lymphoblastic leukemialymphoma accounted for 10 of cases and the rest of the cases were reported as Angioimmunoblastic Tcell lymphoma 7 and Extranodal NKT cell lymphoma nasal type 7Conclusion Appropriate use of immunohistochemistry aids in the subclassification of lymphomas according to the recommendations of WHO 2008 But further molecular studies should be performed for confirmation of the subtyping done by immunohistochemistryKeywords High grade lymphoma Anaplastic large cell lymphoma Peripheral T cell lymphoma
Authors and Affiliations
Priavadhana Rajan Prasaad, Bhawana Ashok Badhe
Keywords
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- EP ID EP475939
- DOI 10.18231/2394-6792.2018.0121
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