Non-hodgkin’s lymphoma: immunohistochemical analysis with clinicopathological correlation”,
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2018, Vol 10, Issue 8
Abstract
Objective: Histomorphology and immunohistochemistry are essential tools for evaluation and classification of lymphoid malignancies. The present prospective study was conducted with the aim to categorize various Non-Hodgkin lymphoid malignancies in lymph node and extranodal biopsies using routine H and E staining and IHC markers based on WHO Classification system 2016 and to study their clinicopathological correlation. Material and methods: The present study was conducted in Department of Pathology at Pt. B D Sharma PGIMS, Rohtak. Hundred cases of Non Hodgkin’s lymphoid malignancy (lymph node and extranodal biopsies) were included in the study. Various histomorphological changes were examined on routine H&E. Cases with provisional diagnosis of lymphoma were further submitted to immunohistochemical staining for a panel of lymphoma markers and classified accordingly. Results: Maximum number of patients were in the age group of 61-70 years (26%). Males were more commonly affected (55%) with a male: female ratio of 1.2:1. Study included 57 cases with nodal and 43 cases with extranodal involvement. Among nodal, cervical (40.4%) was the most common site and among the extranodal, GIT was (27.9%) the most affected site. A significant association was found between presence of B symptoms with male gender and extranodal sites (p<0.05). B Cell type was the commonest type of Non Hodgkin’s lymphoid malignancy observed in the study (80%). The most consistent IHC marker for B cell lymphoma was PAX5 followed by CD20 and CD19 whereas CD5 was the most consistent IHC marker for T cell lymphoma followed by CD3. Conclusion: The distribution of NHL subtypes in India shows important differences with those from the rest of the world. PAX 5 can be used as a universal single pan B cell marker and CD5 as a pan T cell marker in resource poor setting.
Authors and Affiliations
Dr. Vipul Gupta, Dr. Sunita Singh, Dr. Yashika Bhatia, Dr. Shruti Bansal, Dr. Sandeep Yadav, Dr. Rajeev Sen and Dr Anisha
Keywords
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