Non-Invasive Vs Invasive Procedures For Detection of H. Pylori Infection in Patients With Gastric Symptoms in Alkharj, Saudi Arabia
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 1
Abstract
Objectives: H. pylori is detectable in nearly 100% of adult patients with duodenal ulcer and about 80% of patients with gastric ulcer. An association between H. pylori and gastric cancer is confirmed. In developing countries, where most children become infected by the age of 10, gastric cancer rates are very high. Diagnosis of Helicobacter pylori is achieved by invasive or non-invasive methods such as upper endoscopy, antral biopsies, H. pylori PCR of antral biopsies, H. pylori ELISA and H. pylori antigen detection in stool through ELISA technique. The aim of the current study is to compare the diagnostic performance of invasive and non- invasive diagnostic methods in the Kingdom of Saudi Arabia. Design & Methods: Patients between with dyspeptic symptoms were enrolled from the Salman Bin Abdel Aziz University Hospital, Al Kharj, Saudi Arabia between O c t / 2 0 13 and S e p t / 2014. Patients responded to a questionnaire to investigate possible dyspeptic symptoms and then underwent. Besides the gastric biopsy, established as the gold standard test, the stool ELISA test and H. pylori ELISA serology were also applied. Results: The diagnostic performance of the HP stool antigen assay was as follows (Table 2): sensitivity of 94.5%, specificity, 96.2%; positive-predictive value, 93%; negative- predictive value, 94%; and concordance of 90.4%. The diagnostic performance of the H. pylori ELISA assay was also high, with a sensitivity of 90.5% and specificity of 92%. Combining the HP stool antigen with the ELISA assay raised the sensitivity to 98%, the specificity to 97%, PPV to 96% and NPV to 95%. Conclusions: The ROC curve showed a good correlation between the compared methods. The standardization of the ELISA test for the detection of H. pylori in stool specimens constitutes a non-invasive diagnostic alternative
Authors and Affiliations
Ibrahim M. Abdel Aziz
Keywords
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