NON-SPECIFIC IMMUNE REACTIVITY OF WORKERS EXPOSED TO CARBON DISULFIDE
Journal Title: Българско списание за обществено здраве (Bulgarian Journal of Public Health) - Year 2013, Vol 0, Issue 1
Abstract
The aim of the study is to assess the non-specific immune reactivity of workers from viscose rayon production, exposed to carbon disulfide (CS2 ), with respect to the level of exposure. Materials and methods: This study was carried out on 48 exposed workers with different level of carbon disulfide exposure: group I – spinners (20 mg/m3 ), group II – viscose preparatory (4 mg/m3 ) and control group of 23 individuals without chemical exposure. The concentration of CS2 in the air was determined by gas chromatography with mass-spectrometry, non-specific immune reactivity (polymorphonuclear phagocytosis) - by Vymola. The peripheral white blood cells by automatic analyzer were counted and white blood cells differential was manually counted. The obtained results demonstrate suppression of non-specific reactivity in workers exposed to carbon disulfide: the parameters phagocytic ratio, phagocytic number, absolute phagocytic index were significantly decreased in “exposure-effect” and “exposureresponse” relationships. Moderate negative correlation (p<0.01) between percentage of polymorphonuclears and parameters of phagocytosis in high exposure group was found. Conclusion: The suppression of non-specific immune reactivity is related to the level of carbon disulfide exposure and increases the risk of development of infections and other immune outcomes.
Authors and Affiliations
Neliya Dimitrova, Hristina Kopcheva
Keywords
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