Novel Molecular Targets of Azadirachta indica Associated with Inhibition of Tumor Growth in Prostate Cancer
Journal Title: The AAPS Journal - Year 2011, Vol 13, Issue 3
Abstract
The online version of this article (doi:10.1208/s12248-011-9279-4) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Saswati Mahapatra, R. Jeffrey Karnes, Michael W. Holmes, Charles Y. F. Young, John C. Cheville, Manish Kohli, Eric W. Klee, Donald J. Tindall, Krishna Vanaja Donkena
Stratification of Antibody-Positive Subjects by Antibody Level Reveals an Impact of Immunogenicity on Pharmacokinetics
The availability of highly sensitive immunoassays enables the detection of antidrug antibody (ADA) responses of various concentrations and affinities. The analysis of the impact of antibody status on drug pharmacokinetic...
Evaluation of the potential use of poly(ethylene oxide) as tablet- and extrudate-forming material
The purpose of this study was to assess the potential use of poly(ethylene oxide) (PEO) as matrix-forming mate-rial for tablets and extrudates. Raw materials were characterized for size, size distribution, and shape. Tab...
A Novel MDR1 GT1292-3TG (Cys431Leu) Genetic Variation and Its Effect on P-glycoprotein Biologic Functions
P-glycoprotein (P-gp) is a membrane-bound transporter protein that is encoded by the human multidrug resistance gene MDR1 (ABCB1). P-gp recognizes a wide range of xenobiotics, is pivotal in mediating cancer drug resistan...
Computational methods in drug design: Modeling G protein-coupled receptor monomers, dimers, and oligomers
G protein-coupled receptors (GPCRs) are membrane proteins that serve as very important links through which cellular signal transduction mechanisms are activated. Many vital physiological events such as sensory perception...
Intranasal Delivery of Influenza Subunit Vaccine Formulated with GEM Particles as an Adjuvant
Nasal administration of influenza vaccine has the potential to facilitate influenza control and prevention. However, when administered intranasally (i.n.), commercially available inactivated vaccines only generate system...