Novel variant of CYP2D6*6 is undetected by a commonly used genotyping procedure.
Journal Title: Pharmacological Reports - Year 2011, Vol 63, Issue 5
Abstract
We report the identification of a novel and defective variant of the gene encoding cytochrome P450 2D6 (CYP2D6). This novel variant is a subtype of CYP2D6*6 that was undetected by a commercially available 5' exonuclease-based assay. Because the novel variant was found in only one of 609 individuals, it represents a rare subtype of CYP2D6*6 that may be restricted to a single family or a subpopulation. A procedure for the identification of the novel CYP2D6*6 variant using restriction enzyme treatment of amplified fragments was developed.
Authors and Affiliations
Henrik Rasmussen, Thomas Werge
Keywords
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