Novel Vesicular Carrier for Enhanced Transdermal Delivery of Tramadol Hydrochloride Transfersomal Gel
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2011, Vol 6, Issue 3
Abstract
The main aim of current probe is to formulate and evaluate transfersomal gel for effective transdermal delivery of Tramadol Hcl. It was investigated by encapsulating the drug in various formulations which composed of various ratios of phosphatidyl choline, propylene glycol and ethanol prepared by lipid film hydration by conventional rotary evaporation method. The shapes of most Tramadol Hcl-containing Transfersomes were found to be spherical from SEM analysis. The percentage entrapment efficiency of optimised formulation T5 were found to be 92.71±0.56. The prepared formulations had been characterised for the loaded drug amount and vesicle size. The prepared vesicular systems were incorporated into 1% carbopol 934 gel. In vitro skin permeation studies were carried out by cellophane membrane using a Franz diffusion cell. Transfersome gel was found to increase the skin permeation and deposition showing a controlled effect.
Authors and Affiliations
Shastrulagari S. Shivani
Keywords
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