NUCLEO-CYTOPLASMIC ALTERATIONS OF BUCCAL CELLS IN IRON DEFICIENCY ANEMIA.
Journal Title: International Journal of Basic and Applied Physiology - Year 2018, Vol 7, Issue 1
Abstract
Background & Objectives: Although iron deficiency is associated with constant involvement of oral mucosa, the effect of iron on cell cycle inhibitory molecules has been superficially studied. The present study was undertaken to evaluate changes in Nuclear Diameter (ND), Cytoplasmic Diameter (CD) and Nuclear / Cytoplasmic (N/C) Ratio in buccal smears in cases having iron deficiency anemia (IDA). Methods: The study was carried out in the Department of Physiology in collaboration with Department of Medicine at S.M.S. Medical College, Jaipur, Rajasthan. This was a case control type of study. The study group consisted thirty iron deficient cases and thirty controls of age group 20-30 years. Cytoplasmic Diameter (CD), Nuclear Diameter (ND) and Nuclear / Cytoplasmic (N/C) Ratio was assessed from the buccal mucosa and correlated with various hematological parameters. Results: The mean value of ND in IDA was significantly higher as compared to control cohort. Mean N/C ratio was significantly higher as compared to control cohort. On comparing Serum iron with the ND values, moderate negative correlation was found. Regression equations were assessed between Serum Iron and ND and N/C Ratio. Interpretation and Conclusion: The increase in ND and N/C ratio with decrease in serum iron levels suggested that iron deficiency causes significant changes in buccal mucosal cells. Further studies should be conducted to assess the influence of iron on Cell cycle kinases and inhibitors in various cells.
Authors and Affiliations
Nitu Kumari, Namit Garg, Jitendra Gupta, Kapil Gupta, Amitabh Dube
Keywords
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