Nucleotide Variations in microRNA-Binding Sites: The Need of Novel Tools for the Nucleic Acid Alignment
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 15, Issue 4
Abstract
It has been proposed that naturally-occurring variations in microRNAs and their target sites on messenger RNAs may be linked with various human pathologies, including cancer. The growing number of reports clearly indicates the need of the development of complementary sequence alignment algorithms, where the interaction of two complementary RNAs (specifically microRNA and its target mRNA) can be assessed in the context of the multiple single nucleotide polymorphisms. During the last fifteen years, the attention of biologists and medical scientists has been attracted to microRNAs, the small regulatory molecules of about 22 nucleotides long. The suppressive effect of microRNAs on gene expression is well-known and generally attributed to microRNA-mediated degradation of its target messenger RNA (mRNA, the molecule produced by the gene), messenger RNA translational repression, or both. To accomplish this, microRNA aligns with its mRNA target upon the principles of complementarity between the microRNA and mRNA nucleotides [1] (Figure 1). It has been suggested that naturally-occurring variations in microRNAs and their target genes may be associated with various human pathologies including cancer [2,3]. Even substitutions of only one nucleotide, the so-called Single Nucleotide Polymorphisms (SNPs) can either destroy or create microRNA-binding sites, thus, altering microRNA ability to target oncogenes and rendering tumor-suppressor genes susceptible to microRNA-mediated inhibition.
Authors and Affiliations
Jill Zhong, Holly Clifton, Alexander Kofman
Keywords
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- EP ID EP590855
- DOI 10.26717/BJSTR.2019.15.002747
- Views 175
- Downloads 0
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