Occult Hepatitis B in Hemodialysis Patients
Journal Title: Viral Hepatitis Journal - Year 2019, Vol 25, Issue 3
Abstract
Objectives: We aimed to detect occult hepatitis B (OHB) in hemodialysis patients at a higher-risk for OHB. Materials and Methods: The study included 567 patients with chronic renal failure aged 18 years and older who underwent hemodialysis in 10 dialysis centers in İzmir province between May 2013 and July 2013. Hepatitis B surface-antigen (HBsAg), anti-hepatitis B core (HBc) immunoglobulin G (IgG) and anti-HBs were detected by ELISA and HBV-DNA levels with polymerase chain reaction (PCR). Detection of HBsAg negativity with HBV-DNA positivity was considered as OHB. Results: Of 567 patients, 49% were male and the mean age was 62.2 years. All the patients were HBsAg-negative. Isolated anti- HBc IgG positivity was detected in 8 patients while HBV-DNA was negative. Serum HBV-DNA level was 270 IU/mL in only one patient (0.2%) who was anti-HBc IgG-negative. Conclusion: HBsAg alone is not an adequate serological test to detect HBV infection. HBV-DNA should be tested using molecular diagnostic methods in patients with suspected OHB. Further studies investigating cost-effectiveness and the role of PCR in diagnosis are warranted.
Authors and Affiliations
Pelin Adar, Şükran Köse, Bengü Tatar
Keywords
Related Articles
- EP ID EP676544
- DOI 10.4274/vhd.galenos.2019.2018.0009
- Views 188
- Downloads 0
HBV Flare Under Tenofovir Treatment in Chronic Hepatitis B: Case Report
The purpose of chronic hepatitis B treatment is to stop the progression of the disease and prevent cirrhosis and liver cancer that may occur with the progression of the disease. In the current treatment, one of the nucle...
Evaluation of Serum CTNNβ1 and E-cadherin Levels in Hepatitis Patients
Objectives: Hepatitis B virus (HBV) infection is one of the leading causes of hepatocellular carcinoma, but the underlying molecular mechanisms are quite complex. In this study, the aim was to reveal the relationship of...
Genotype Distributions and Hepatitis B Coinfection in Hepatitis C Patients at a University Hospital
Objectives: Hepatitis C virus (HCV) infection is a major cause of chronic liver disease. Comorbidity with the hepatitis B virus (HBV) leads to progressive fibrosis and severe liver disease. Our study aimed to determine H...
Genotyping Distribution of Hepatitis C Virus in Şanlıurfa Province and Effect of Syrian Patients
Objectives: Hepatitis C virus (HCV) is one of the major causes of global mortality and morbidity. The purpose of our study was to characterize the distribution of HCV genotypes in Şanlıurfa, to see the effect of patients...
The Efficacy of Paritaprevir/Ritonavir/Ombitasvir/Dasabuvir with or without Ribavirin in Patients with Hepatitis C Undergoing Chronic Haemodialysis: A Single Center Experience
Objectives: Paritaprevir/Ritonavir/Ombitasvir/Dasabuvir (PrOD) seems to be highly effective and safe in chronic haemodialysis (CHD) patients. We presented our experiences of treatment with PrOD in CHD patients. Material...