Ocimum Gratissimum Linn Causes Dose Dependent Hepatotoxicity in Streptozotocin-Induced Diabetic Wistar Rats
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2012, Vol 5, Issue 1
Abstract
Aim: Hepatoprotective effects of Ethanolic extract Ocimum gratissimum leaves (O. gratissimum) in streptozotocin-induced diabetic rats was studied. Material and Methods: Thirty-six adult rats were assigned into six groups (A, B, C, D, E and F) of six rats each. Group A was the control, while diabetes was induced in groups B, C, D, E and F. Fasting blood glucose was determined and rats with blood glucose concentration >18.0 mmol/L were considered diabetic. Group A (non diabetic control) and F (diabetic control) received normal saline orally, group B received a Metformin at 25 mg/kg while groups C, D and E had O. gratissimum at 400, 600 and 800 mg/ kg. Treatment was daily for a period of 28 days for all groups. Fasting blood glucose was monitored weekly, serum levels of Alanine transaminase (ALT) and Aspartate transaminase (AST) were measured on day twenty eight. Animals were sacrificed, liver sections processed for histological study. Statistical analysis was carried out using a one way ANOVA followed by a post-hoc test. Results: Results showed reduction in blood sugar and increase in biochemical and histologic markers of hepatic injury. Conclusion: Ethanolic extract of O. gratissimum causes dose dependent hepatic injury despite its glucose lowering ability.
Authors and Affiliations
Adejoke Y Onaolapo| Department of Human Anatomy, Ladoke Akintola University of Technology, Ogbomoso, Oyo state, Nigeria, Olakunle J Onaolapo| Department of Pharmacology and Therapeutics, Ladoke Akintola University of Technology, Ogbomoso, Oyo state, Nigeria
Keywords
Related Articles
- EP ID EP8841
- DOI 10.3889/MJMS.1857-5773.2011.0206
- Views 340
- Downloads 15
Effects of Varying Doses of Plain Bupivacaine with Fentanyl in Patients Undergoing Cesarean Section: Haemodinamics and Neonatal Outcome
Aim. The purpose of this study was to evaluate a three different regimes of spinal anaesthesia for caesarean delivery as well the incidence and severity of maternal hypotension and its influence over neonatal outcome....
Functional Analysis of Mutahassaneen Area during Hajj 1427Hijra
Objective. This study highlighted the activity of Mutahassaneen Area during Hajj-1427 Hijra (H). Methodology. This Study was a retrospective observational review of those Hajj patients who stayed in the Mutahassaneen A...
Use of Dorsal Metacarpal Artery Flaps in Post Burn Reconstruction – Two Cases Report
Perforator flaps based on the dorsal metacarpal arteries, islanded on a reverse flow pattern are used for reconstruction of two patients respectively with an unstable scar located on the MCP joints and a severe contrac...
Renal Transplant in an Adult with Ellis Van Creveld Syndrome: A Case Report and Literature Review
Ellis van Creveld syndrome (EVC) is a rare chrondro-ectodermal dysplasia. Renal abnormalities are found in few EVC cases with agenesis, dysplasia, megaureter and nephrocalcinosis. Rarely EVC syndrome is complicated wit...
Electrophysiological Evaluation of the Incidence of MartinGruber Anastomosis in Healthy Bosnian Population
Background: Martin-Gruber anastomosis (MGA) is the well known anostomosis that occur at the various levels between the median and ulnar nerves. This anastomosis involves axons leaving either the main trunk of median ne...