ONCOGENICITY OF TOBACCO-SMOKING: A REVIEW ON SQUAMOUS CELL CARCINOMA OF THE TONGUE, DIAGNOSIS AND TREATMENT
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2018, Vol 4, Issue 12
Abstract
Squamous cell carcinoma (SCC) of the tongue is the commonest type of tongue cancer affecting young smokers and older men (over 45 years of age) than women. It represents more than ninety percent of all head and neck cancers, and occurs mainly in the lateral posterior border that may extend to the dorsum of the tongue. The major risk factors for SCC of the tongue are tobacco-smoking (to a greater extent) and frequent consumption of large amounts of alcohol (to a smaller extent). Minor risk factors for SCC of the tongue include irritation induced by chewing tobacco, dental caries, overuse of mouthwash, chewing betel nut and oral human papillomavirus (HPV) acquired via genito-oral route. The early stages of SCC of the tongue are usually asymptomatic, but later stages may present as lesions that appear as areas of erythroplakia or leukoplakia, with ulceration and pain usually at the base of the tongue, and consequently a lump or an induration on the tongue. Diagnosis of SCC of the tongue involves taking a medical history and physical examination of the tongue for unhealed ulcers and nearby lymph nodes for swelling. If SCC of the tongue is suspected, a biopsy of affected areas of the tongue is made, followed by processing of the biopsied tissue and preparation of smears on clean grease-free glass slides. Finally, the smears are stained with the „„Haematoxylin and Eosin (H & E) stain‟‟, and then examined under the microscope. The presence of intense pleomorphism, nuclear hyperchromatism, increased nuclear to cytoplasmic ratio, and increased proliferation of epithelial cells is diagnostic of SCC of the tongue. Treatment of this disease involves glossectomy, with postoperative radiation or chemo-radiation. It is not new that tobacco-smoking via cigarettes and shishas, as well as regular consumption of large volumes of alcohol among the elderly and especially young people is rapidly on the increase. Thus, this review was aimed at discussing the consequence of tobacco-smoking with focus on Squamous Cell Carcinoma of the Tongue, its diagnosis and treatment. It is therefore highly recommended that tobacco-smoking, as well as chronic consumption of alcohol be avoided, and that these artisans (smokers and alcoholics) should get themselves examined medically.
Authors and Affiliations
Onengiyeofori Ibama
Keywords
Related Articles
- EP ID EP656533
- DOI -
- Views 188
- Downloads 0
e-MEDICINE PROVIDES 24 HOURS WEEKLY NONSTOP SERVICE TO THE BEST OF MANKIND
e-medicine is serving to the human by following 24 hours weekly without any fail for best and prompt medical help. Just as the printing press democratized information, the medicalized smartphone will democratize health c...
MANAGEMENT OF KIKKISA (STRIAE GRAVIDARUM) IN GARBHINI PARICHARYA (ANTENATAL CARE)
Motherhood is the crowning act in the feminine role of life. She cannot escape from the happenings occurring in reproductive age. Stretch marks are one such type of happenings that occurs at the time of pregnancy. Striae...
MOTHER AND CHILD CARE THROUGH YOGA AND NATUROPATHY
Pregnancy is the process whereby the life of a baby begins in the mother’s womb and progresses up to the stage when it is safe to expose the baby to the outside world. Pregnancy is a very precious and important event in...
PERICARDIAL EFFUSION IN CASES OF MYOCARDIAL INFARCTION
Objective: To determine the frequency of pericardial effusion in cases of Myocardial Infarction. Methodology: This was a cross sectional study that was carried out at Lahore General Hospital, Lahore during November 2017...
USE OF KUMARI AND SPHATIKA NETRABINDU ASCHOTAN IN OPHTHALMALGIA
Today‟s era, due to change in the life style eye disease increases gradually. Pain in the eye (ophthalmagia) may be described as a dry eye, watering, burning, throbbing, aching, or stabbing sensation in or around the eye...