ONE-POT SYNTHESIS OF 2,4,5-TRIARYLIMIDAZOLES FROM KETO-OXIMES: CHARACTERIZATION AND EVALUATION OF ANTIMICROBIAL ACTIVITY
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 9
Abstract
Background and Objective: Imidazole scaffold is pervasive in pharmaceuticals and it possesses diverse type of biological activities, especially triarylimidazole derivatives are biologically prominent molecules which inspired the current investigation. The objective of the work is to synthesize 15 novel 2,4,5-triarylimidazole derivatives and evaluate their antimicrobial and antimycobacterial activity against selected bacterial and fungal strains. Methods: The title compounds 2,4,5-triaryl-imidazole were synthesized from the corresponding aryl aldehydes and keto-oximes through the cyclization to N-hydroxyimidazoles and reduced thermally to the different imidazole derivatives. Agar disc diffusion method is employed for the antimicrobial and antimycobacterial studies. Results: Fifteen novel 2,4,5-triarylimidazoles were synthesized in adequate yields and characterization of the molecules was done by detailed spectral analysis using advanced analytical support. Results disclosed that all the synthesized compounds were exhibiting antimicrobial properties. Compounds 3h, 3g, 3b, and 3m were stated to possess potent antimicrobial properties in the given bacterial and fungal strains. Conclusion: The current investigation results support the antimicrobial and antimycobacterial activity of the synthesized 2,4,5-triarylimidazole derivatives. Further, research is necessary to explore the mechanism involved in the antimicrobial activity.
Authors and Affiliations
KRANTHI KUMAR T , SREENIVASULU R
Keywords
Related Articles
- EP ID EP646654
- DOI -
- Views 116
- Downloads 0
NEUROIMMUNO MODULATION BY VESTIBULAR STIMULATION IN COLD WATER SWIMMING STRESS INDUCED WISTAR ALBINO RATS
ABSTRACTObjectives: We hypothesized that vestibular stimulation prevents stress-induced suppression of immunity by inhibiting the stress axes and to testthis hypothesis total leucocyte count, differential leucocyte count...
EFFECT OF URANIUM NITRICUM IN LM POTENCIES ON REDUCTION IN CARDIOVASCULAR RISK AMONG PATIENT WITH TYPE 2 DIABETES MELLITUS
Objectives: The present study was carried to determine the reduction in cardiovascular (CV) risk among the patients with type 2 diabetes mellitus (T2DM) after treatment with homeopathic uranium nitricum in LM potencies o...
DEVELOPMENT AND IN VITRO EVALUATION OF SOLID DISPERSIONS OF CANDESARTAN CILEXETIL
Objective The main objective of the present study is systematic development of solid dispersions of Candesartan cilexetil by solvent evaporation method to enhance the solubility and bioavailability. Methods In the pre...
ANALYTICAL METHOD DEVELOPMENT & VALIDATION OF ETRAVIRINE IN ITS BULK DOSAGE FORM BY USING RP-HPLC METHOD AS PER ICH GUIDELINES
 Objective: An accurate, precise, rapid and economical reverse phase high performance liquid chromatography (HPLC) method has been developedand validated for the estimation of etravirine in pharmaceutical dosage forms,...
PHARMACOKINETIC COMPARISON OF MONTELUKAST SODIUM FORMULATIONS AFTER A SINGLE ORAL DOSE IN HEALTHY GUINEA PIGS
Objective: Pharmacokinetic evaluation of montelukast sodium chronomodulated capsules (sustained-release solid dispersion of drug enclosed in pH-sensitive film-coated hard gelatin shell) and marketed tablets has been carr...