Optimization For Improving Biomass And Antioxidant Activity From Lactobacillus Acidophilus
Journal Title: International Journal of Pharmaceutical Science Invention - Year 2018, Vol 7, Issue 4
Abstract
Lactobacillus acidophilus is an important probiotic in many countries. The demand for biomass of this bacterium is huge. In recent years, the antioxidant activity of Lactobacillus is concerned and exploited. However, the low yield severely hindered advance study and application of itsantioxidant activity. In this study, we conducted fermentation experiment using Lactobacillus acidophilus in de Man-Rogosa-Sharpe. The glucose content in this environment is replaced by 6% sucrose solution. Optimal fermentation conditions were determined by experimental planning method and Box-Wilson method including pH 5.1, temperature at 36.6oC andreaction time in 40hour. At this fermentation conditions, the biomass obtained was 11.589±0.09 log (CFU/ml) (6.4% increase). Lactobacillus acidophilus BK4 showed reducing power was 0.551±0.04 (37.8% increase) and 1,1-diphenyl 2-picrylhydrazyl (DPPH) scavenging activities, with inhibition rates of 53.63% (12.02% increase). The biomass and the yield of antioxidant activity from Lactobacillus acidophilus BK4 is significantly improved which satisfies the requirement for advance study and application.
Authors and Affiliations
Luong Ngoc Anh, Nguyen Thuy Huong
Keywords
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